Brain of the tree pangolin (Manis tricuspis). III. The unusual locus coeruleus complex
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24519
Abstract: Here, we used a range of immunohistochemical stains, focussing on tyrosine hydroxylase and dopamine‐β‐hydroxylase, to show that within the pons of tree pangolins clusters of noradrenergic neurons are present. No noradrenergic neurons were observed in… read more here.
Keywords: locus coeruleus; noradrenergic neurons; tree pangolin; coeruleus complex ... See more keywords
Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.054
Abstract: Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders. Such disorders are often treated by drugs targeting the CNS norepinephrine system. Despite roles… read more here.
Keywords: differences noradrenergic; sex differences; locus coeruleus; sex ... See more keywords
Cellular composition and circuit organization of the locus coeruleus of adult mice
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.1101/2022.03.01.481656
Abstract: The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in the brain and regulates many fundamental functions including fight and flight response, attention control, and sleep/wake cycles. While efferent projections of the LC… read more here.
Keywords: noradrenergic neurons; circuit organization; locus coeruleus;
No loss of orexin/hypocretin, melanin‐concentrating hormone or locus coeruleus noradrenergic neurons in a rat model of chronic sleep restriction
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15412
Abstract: Chronic sleep restriction (CSR) is common in modern society, adversely affecting cognitive performance and health. Yet how it impacts neurons regulating sleep remains unclear. Several studies using mice reported substantial losses of wake‐active orexin/hypocretin and… read more here.
Keywords: orexin; protocol; noradrenergic neurons; chronic sleep ... See more keywords
Carbachol increases locus coeruleus activation by targeting noradrenergic neurons, inhibitory interneurons and inhibitory synaptic transmission
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15866
Abstract: The locus coeruleus (LC) consists of noradrenergic (NA) neurons and plays an important role in controlling behaviours. Although much of the knowledge regarding LC functions comes from studying behavioural outcomes upon administration of muscarinic acetylcholine… read more here.
Keywords: application; noradrenergic neurons; synaptic transmission; locus coeruleus ... See more keywords
Activity of pontine A7 noradrenergic neurons is suppressed during REM sleep
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Physiology"
DOI: 10.1152/japplphysiol.00771.2021
Abstract: The activity of hypoglossal motoneurons plays a key role in the maintenance of upper airway patency. The withdrawal of noradrenergic excitatory drive and increase of cholinergic inhibition markedly decreases excitability of hypoglossal motoneurons during sleep… read more here.
Keywords: noradrenergic neurons; pontine noradrenergic; rem sleep; hypoglossal ... See more keywords
Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for adult breathing
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732285
Abstract: Central noradrenergic (NA) neurons are key constituents of the respiratory homeostatic network. NA dysfunction is implicated in several developmental respiratory disorders such as Sudden Infant Death Syndrome (SIDS) and Rett Syndrome. Previous studies suggest that… read more here.
Keywords: noradrenergic neurons; glutamatergic signaling; physiology; vglut2 based ... See more keywords
ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.39907
Abstract: Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates… read more here.
Keywords: mania like; locus coeruleus; erbb4 deletion; deletion noradrenergic ... See more keywords