Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
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DOI: 10.1002/cmdc.201800804
Abstract: The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an… read more here.
Keywords: norcarbocyclic nucleoside; nucleoside phosphonates; antiviral evaluation; evaluation fluoro ... See more keywords
Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
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DOI: 10.3390/molecules24193433
Abstract: Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains.… read more here.
Keywords: analogues antiprotozoal; antiprotozoal antibacterial; norcarbocyclic nucleoside; nucleoside analogues ... See more keywords
Synthesis and Antiviral Evaluation of 3′-Fluoro-5′-norcarbocyclic Nucleoside Phosphonates Bearing Uracil and Cytosine as Potential Antiviral Agents
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DOI: 10.3390/molecules25163708
Abstract: Carbocyclic nucleoside analogues are an essential class of antiviral agents and are commonly used in the treatment of viral diseases (hepatitis B, AIDS). Recently, we reported the racemic synthesis and the anti-human immunodeficiency virus activities… read more here.
Keywords: synthesis antiviral; norcarbocyclic nucleoside; nucleoside phosphonates; antiviral agents ... See more keywords