Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation.
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DOI: 10.1016/j.bbrc.2018.10.120
Abstract: Reactive oxygen species (ROS) modulate neuronal function, including plasticity and neurotransmitter biosynthesis and release. The cellular mechanisms that underlie redox modulation of neurotransmission are not fully resolved, but potential pathways include ROS-induced alterations in Ca2+… read more here.
Keywords: trpm8 channel; oxidant induced; pc12 cells; norepinephrine secretion ... See more keywords