Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02180-4
Abstract: The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also used in the therapeutic applications against certain… read more here.
Keywords: norepinephrine transporter; system; net; radiotracers targeting ... See more keywords
QSAR modeling, molecular docking and ADMET/pharmacokinetic studies: a chemometrics approach to search for novel inhibitors of norepinephrine transporter as potent antipsychotic drugs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-01902-5
Abstract: Chemometrics study that relates biological activity to physicochemical descriptors of a molecule and the prediction of absorption, distribution, metabolism, excretion and toxicity (ADMET) properties in advance are important steps in drugs discovery. In this study,… read more here.
Keywords: norepinephrine transporter; chemometrics approach; admet pharmacokinetic; inhibitors norepinephrine ... See more keywords
Hunger and disinhibition but not cognitive restraint are associated with central norepinephrine transporter availability
Sign Up to like & getrecommendations! Published in 2017 at "Appetite"
DOI: 10.1016/j.appet.2017.06.020
Abstract: The relationship between food-intake related behaviours measured by the Three-Factor Eating Questionnaire (TFEQ) and in vivo norepinephrine transporter (NET) availability has not been explored yet. We investigated ten obese individuals (body mass index (BMI) 42.4 ± 3.7 kg/m2) and… read more here.
Keywords: availability; cognitive restraint; norepinephrine transporter; disinhibition ... See more keywords
Oxytocin modulates the expression of norepinephrine transporter, β3-adrenoceptors and muscarinic M2 receptors in the hearts of socially isolated rats
Sign Up to like & getrecommendations! Published in 2019 at "Peptides"
DOI: 10.1016/j.peptides.2018.06.008
Abstract: HIGHLIGHTSOxytocin treatment exhibits anxiolytic effect.Prolonged oxytocin prevents hypetrophy of cardiomyocytes.Oxytocin enhances norepinephrine uptake.Oxytocin led to enhancement gene expression of &bgr;3‐AR and M2 MR. ABSTRACT Social stress produces behavioral alterations, and autonomic and cardiac dysfunction in… read more here.
Keywords: norepinephrine transporter; treatment; socially isolated; muscarinic receptors ... See more keywords
Novel [18F]-Labeled Meta-Bromobenzylguanidine Derivatives: Potential Positron Emission Tomography Imaging Probes for the Norepinephrine Transporter.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00429
Abstract: To develop novel norepinephrine transporter (NET)-targeting positron emission tomography (PET) probes with optimal pharmacokinetic properties, a series of meta-bromobenzylguanidine derivatives was synthesized. 4-Fluorodiethoxyethane-3-bromobenzylguanidine (compound 12) showed relatively good affinity for the NET (IC50 = 1.00… read more here.
Keywords: norepinephrine transporter; labeled meta; positron emission; bromobenzylguanidine derivatives ... See more keywords
The norepinephrine transporter deserves more attention.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000001757
Abstract: N orepinephrine released from adrenergic nerve terminals in heart, kidney, and vasculature is crucial for blood pressure (BP) regulation. Both, too little and too much norepinephrine perturbs cardiovascular regulation. Lifewithout norepinephrine ismiserable as exemplified by… read more here.
Keywords: transporter deserves; attention; norepinephrine transporter; hypertension ... See more keywords
Differential Genetic Effect of the Norepinephrine Transporter Promoter Polymorphisms on Attention Problems in Clinical and Non-clinical Samples
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.01051
Abstract: Among the monoaminergic modulatory neurotransmitters, norepinephrine is involved in task orienting, hence noradrenergic genetic variants have been studied in connection to attentional processes. The role of this catecholamine system is also highlighted by the selective… read more here.
Keywords: attention; norepinephrine transporter; attention problems; promoter ... See more keywords
Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12080965
Abstract: Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or… read more here.
Keywords: norepinephrine transporter; net availability; therapy; availability ... See more keywords
Anticancer Efficacy and Mechanisms of a Dual Targeting of Norepinephrine Transporter and Thyrointegrin αvβ3 Antagonist in Neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.72522
Abstract: Background: In neuroendocrine tumors, the norepinephrine transporter (NET) is very active and has been exploited for diagnostic imaging purposes and/or therapy with localized radiotherapy. Integrin αvβ3 is generously expressed by and/or activated on cancer cells,… read more here.
Keywords: p400 tat; norepinephrine transporter; dual targeting; targeting norepinephrine ... See more keywords