Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice
Sign Up to like & getrecommendations! Published in 2021 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2021.111437
Abstract: Highlights • Transcriptomic changes are more similar within mutant mice that show either lengthened or shortened lifespan.• The major transcriptomic differences between long- and short-lived mice are in genes controlling mitochondrial metabolism.• Gene expression changes… read more here.
Keywords: mutant mice; normal ageing; long short; mitochondrial metabolism ... See more keywords
Normal ageing of the brain: Histological and biological aspects.
Sign Up to like & getrecommendations! Published in 2020 at "Revue neurologique"
DOI: 10.1016/j.neurol.2020.03.017
Abstract: All the hallmarks of ageing are observed in the brain, and its cells, especially neurons, are characterized by their remarkably long lifetime. Like any organ or system, the brain is exposed to ageing processes which… read more here.
Keywords: normal ageing; ageing brain; brain histological; biological aspects ... See more keywords
How do "Young-old" Adults project their Self? A Study of Self-defining Future Projections in normal Ageing.
Sign Up to like & getrecommendations! Published in 2023 at "Current aging science"
DOI: 10.2174/1874609816666230330092556
Abstract: BACKGROUND Self-defining future projections (SDFP) are mental representations of plausible and highly significant future events that provide core information of one's understanding of self. OBJECTIVE We explored SDFPs in a large sample of older adults… read more here.
Keywords: old adults; self defining; future projections; normal ageing ... See more keywords