A Neuroimaging Signature of Cognitive Aging from Whole‐Brain Functional Connectivity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201621
Abstract: Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two… read more here.
Keywords: network; normal aging; brain; functional connectivity ... See more keywords
Characteristics of perivascular space dilatation in normal aging
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26277
Abstract: The increased incidence of dilated perivascular spaces (dPVSs) visible on MRI has been observed with advancing age, but the relevance of PVS dilatation to normal aging across the lifespan has yet to be fully clarified.… read more here.
Keywords: pvs dilatation; normal aging; age; dilatation normal ... See more keywords
Behavioral and neural correlates of normal aging effects on motor preparatory mechanisms of speech production and limb movement
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Brain Research"
DOI: 10.1007/s00221-019-05549-4
Abstract: Normal aging is associated with decline of the sensorimotor mechanisms that support movement function in the human brain. In this study, we used behavioral and event-related potential (ERP) recordings to investigate the effects of normal… read more here.
Keywords: movement; speech production; motor preparatory; normal aging ... See more keywords
Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse models
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.06.002
Abstract: GRAPHICAL ABSTRACT Figure. No caption available. HIGHLIGHTSProteomics detects 36 hippocampal proteins associated with AD and normal aging memory deficits.Pathway analysis highlights HDAC4 as global regulator of memory deficits.103 proteins differ specifically in AD mice with… read more here.
Keywords: alzheimer disease; normal aging; pathways associated; memory deficits ... See more keywords
Decreased Dynamic Segregation but Increased Dynamic Integration of the Resting-state Functional Networks During Normal Aging
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DOI: 10.1016/j.neuroscience.2020.04.030
Abstract: A hallmark of the aging process is increased connectivity between networks and decreased connectivity within networks, which to some extent reflects the reorganization of the brain networks during normal aging. Considering the brain as a… read more here.
Keywords: network; integration; normal aging; segregation ... See more keywords
Normal aging changes in the choroidal angioarchitecture of the macula
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DOI: 10.1038/s41598-020-67829-2
Abstract: The choroidal vascularity index (CVI) has been shown to be sensitive in detecting changes in choroidal angioarchitecture in a range of ocular diseases. However, changes in CVI in association with normal physiological aging and spatial… read more here.
Keywords: macula; age; changes choroidal; normal aging ... See more keywords
Multivariate morphometry statistics reveal the morphological change pattern of hippocampus during normal aging
Sign Up to like & getrecommendations! Published in 2022 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001810
Abstract: There have been numerous studies focusing on normal aging in previous decades which is accompanied by the structural and functional decline in the hippocampus, while the pattern of hippocampal alteration with age remains unclear. Figuring… read more here.
Keywords: morphometry statistics; multivariate morphometry; normal aging; age ... See more keywords
Normal Aging and Its Role in Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a037341
Abstract: Metastasis is the most common cause of death, with treatments failing to provide a durable response. Aging is a key prognostic factor in many cancers. Emerging data suggest that normal age-related changes in the tumor… read more here.
Keywords: age; cancer metastasis; metastasis; role cancer ... See more keywords
Disentangling Normal Aging from Severity of Disease via Weak Supervision on Longitudinal MRI.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE transactions on medical imaging"
DOI: 10.1109/tmi.2022.3166131
Abstract: The continuous progression of neurological diseases are often categorized into conditions according to their severity. To relate the severity to changes in brain morphometry, there is a growing interest in replacing these categories with a… read more here.
Keywords: via weak; weak supervision; aging severity; disease ... See more keywords
Mapping microstructural gradients of the human striatum in normal aging and Parkinson’s disease
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DOI: 10.1126/sciadv.abm1971
Abstract: Mapping structural spatial change (i.e., gradients) in the striatum is essential for understanding the function of the basal ganglia in both health and disease. We developed a method to identify and quantify gradients of microstructure… read more here.
Keywords: striatum; normal aging; disease; parkinson disease ... See more keywords
Markers of Alzheimer's Disease in Primary Visual Cortex in Normal Aging in Mice
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/3706018
Abstract: Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1–42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas… read more here.
Keywords: cortex; alzheimer disease; normal aging; mice ... See more keywords