Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2954-1
Abstract: One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian… read more here.
Keywords: chemotherapy; normal cells; biology; ovarian cancer ... See more keywords
Co-Culturing Cancer Cells and Normal Cells in a Biochip under Electrical Stimulation
Sign Up to like & getrecommendations! Published in 2018 at "BioChip Journal"
DOI: 10.1007/s13206-018-2309-x
Abstract: The ideal cancer therapeutic strategy is to inhibit the tumor with minimal influence on the normal tissue. Recently, applying an alternating electric field for inhibiting tumor was developed; but, it has not been adopted to… read more here.
Keywords: cells normal; normal cells; cancer cells; cancer ... See more keywords
Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.031
Abstract: Oncogenic transformation enables cells to behave differently from their neighboring normal cells. Both cancer and normal cells recognize each other, often promoting the extrusion of the former from the epithelial cell layer. Here, we show… read more here.
Keywords: normal cells; rasv12 transformed; towards basal; side surrounding ... See more keywords
Selective killing of transformed cells by mechanical stretch.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120866
Abstract: Cancer cells differ from normal cells in several important features like anchorage independence, Warburg effect and mechanosensing. Further, in recent studies, they respond aberrantly to external mechanical distortion. Consistent with altered mechano-responsiveness, we find that… read more here.
Keywords: transformed cells; normal cells; selective killing; tumor cells ... See more keywords
Design, synthesis, and biological activities of 1-aryl-(3-(2-styryl)phenyl)prop-2-en-1-ones.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.005
Abstract: A moderate elevation in reactive oxygen species (ROS) levels can generally be controlled in normal cells, but may lead to death of cancer cells as the ROS level in cancer cells is already elevated. Therefore,… read more here.
Keywords: design synthesis; normal cells; biological activities; cancer cells ... See more keywords
Cellular uptake and apoptotic potential of rhenium labeled magnetic protein cages in MDA-MB-231 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2018.08.014
Abstract: 188Re-magnetoferritin nanoparticles (NPs) provide an attractive platform for localized radiation therapy due to their magnetic targeting capability while enhancing contrast in magnetic resonans imaging (MRI) signals. In this study, cellular uptake, in vitro cytotoxicity, apoptotic… read more here.
Keywords: normal cells; apoptotic potential; rhenium; cancer cells ... See more keywords
HuR translocation to the cytoplasm of cancer cells in actin‐independent manner
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.05.021
Abstract: Abstract Human antigen R (HuR) is a RNA‐binding protein, which binds to the AU‐rich element (ARE) in the 3′‐untranslated region (3′‐UTR) of certain mRNA and is involved in the export and stabilization of ARE‐mRNA. HuR… read more here.
Keywords: normal cells; hur; hur transport; cancer cells ... See more keywords
New unsymmetrical bisacridine derivatives non-covalently attached to quaternary quantum dots improve cancer therapy via enhancing cytotoxicity towards cancer cells and protecting normal cells.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c02621
Abstract: The use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in… read more here.
Keywords: normal cells; new unsymmetrical; cancer cells; cancer ... See more keywords
Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b03211
Abstract: Specific imaging of cancer cells has been well-accepted in cancer diagnosis although it cannot precisely mark the boundary between the normal and cancerous cells and report their mutual influence. We report a nanorod fluorescent probe… read more here.
Keywords: better cancer; normal cells; copper; cancer ... See more keywords
Bleomycin-induced genome structural variations in normal, non-tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34580-8
Abstract: Many anticancer drugs are genotoxic agents inducing DNA breaks in actively proliferating cancer cells. However, these same drugs also induce mutations, mostly genome structural variations (GSVs). The detection of GSVs in normal cells and tissues… read more here.
Keywords: bleomycin induced; structural variations; normal cells; normal non ... See more keywords
Development of accurate temperature regulation culture system with metallic culture vessel demonstrates different thermal cytotoxicity in cancer and normal cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00908-0
Abstract: Hyperthermia has been studied as a noninvasive cancer treatment. Cancer cells show stronger thermal cytotoxicity than normal cells, which is exploited in hyperthermia. However, the absence of methods evaluating the thermal cytotoxicity in cells prevents… read more here.
Keywords: normal cells; temperature; cancer; culture ... See more keywords