Multi-omic analysis in normal colon organoids highlights MSH4 as a novel marker of defective mismatch repair in Lynch syndrome and microsatellite instability.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6048
Abstract: INTRODUCTION Lynch syndrome (LS) is a hereditary condition that increases the risk of colorectal (CRC) and extracolonic cancers that exhibit microsatellite instability (MSI-H). MSI-H is driven by defective mismatch repair (dMMR), and approximately 15% of… read more here.
Keywords: normal colon; expression; colon organoids; lynch syndrome ... See more keywords
Classification of colorectal primer carcinoma from normal colon with mid‐infrared spectra
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemometrics"
DOI: 10.1002/cem.3542
Abstract: In this project, we used formalin‐fixed paraffin‐embedded (FFPE) tissue samples to measure thousands of spectra per tissue core with Fourier transform mid‐infrared spectroscopy using an FT‐IR imaging system. These cores varied between normal colon (NC)… read more here.
Keywords: colorectal primer; mid infrared; primer carcinoma; normal colon ... See more keywords
Epigenetic conservation infers that colorectal cancer progenitors retain the phenotypic plasticity of normal colon
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DOI: 10.1038/s41598-025-24703-3
Abstract: Plasticity, or the ability to rapidly and reversibly change phenotypes, may help explain how a single progenitor cell eventually generates a tumor with many different cell phenotypes. Normal colon plasticity is characterized by a conserved… read more here.
Keywords: phenotypic plasticity; plasticity normal; plasticity; normal colon ... See more keywords
Oxidative stress induced by tBHP in human normal colon cells by label free Raman spectroscopy and imaging. The protective role of natural antioxidants in the form of β-carotene
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra01950c
Abstract: The present study aimed to investigate the protective effect of β-carotene on the oxidative stress injury of human normal colon cell line CCD-18Co triggered by tert-butyl hydroperoxide (tBHP). XTT examination was used to determine cell… read more here.
Keywords: carotene; normal colon; label free; spectroscopy ... See more keywords
Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples
Sign Up to like & getrecommendations! Published in 2020 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672920040122
Abstract: Abstract Human colorectal adenocarcinoma cell line Caco-2 is often used as a model of healthy intestinal epithelium, in particular, in miRNA studies. The work of the enzymes Drosha and Dicer is an integral part of… read more here.
Keywords: colon tissue; normal colon; drosha dicer; differences drosha ... See more keywords
Abstract LB231: Somatic evolution in normal colon of patients with and without cancer
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-lb231
Abstract: Introduction: While somatic mutations in colorectal cancer (CRC) are well characterized, little is known about the accumulation of cancer-associated mutations in normal colon. This knowledge is crucial to understand the origin and evolution of cancer… read more here.
Keywords: patients without; patients crc; without cancer; cancer ... See more keywords
Genome-wide DNA methylation profiles of colorectal tumors in Lynch syndrome and familial adenomatous polyposis
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DOI: 10.1186/s13148-025-01940-x
Abstract: Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are hereditary cancer predisposing syndromes characterized by increased risk of especially early-onset colorectal cancer. Predisposition to LS is caused by germline mutations in DNA mismatch repair genes… read more here.
Keywords: genome wide; dna methylation; methylation; normal colon ... See more keywords
The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051491
Abstract: Simple Summary Colorectal cancer is the second leading cause of cancer-related deaths in the United States with an overall 5-year survival of 65%. While there have been many advances in the treatment of this disease… read more here.
Keywords: family; normal colon; expression profiles; mucin family ... See more keywords