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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09447-z
Abstract: Normal fibroblasts surrounding tumor cells play a crucial role in cancer progression through formation of the tumor microenvironment. Because factors secreted from normal fibroblasts can modulate the tumor microenvironment, it is necessary to identify key…
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Keywords:
cancer;
normal fibroblasts;
tumor microenvironment;
lung cancer ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5840
Abstract: It has become increasingly apparent that cancer is not a tumor cell-centric disease. Elements of the tumor microenvironment (TME), including fibroblasts and senescent cells, have been shown to contribute to tumor cell proliferation, metastasis, and…
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Keywords:
abt 263;
sensitivity;
ags cells;
fibroblasts senescent ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218119
Abstract: Collagen, the main non-cellular component of the extracellular matrix (ECM), is profoundly reorganized during tumorigenesis and has a strong impact on tumor behavior. The main source of collagen in tumors is cancer-associated fibroblasts. Cancer cells…
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Keywords:
normal fibroblasts;
colorectal cancer;
collagen remodeling;
cancer cells ... See more keywords
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Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.69178
Abstract: Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an essential role in modulating inflammatory responses and extracellular matrix remodeling. However, little is known regarding the role of TSG-6 in human…
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Keywords:
cancer;
normal fibroblasts;
pro metastatic;
tsg ... See more keywords