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   Articles with "normal fibroblasts" as a keyword



TRAF4 promotes lung cancer aggressiveness by modulating tumor microenvironment in normal fibroblasts

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-09447-z

Abstract: Normal fibroblasts surrounding tumor cells play a crucial role in cancer progression through formation of the tumor microenvironment. Because factors secreted from normal fibroblasts can modulate the tumor microenvironment, it is necessary to identify key… read more here.

Keywords: cancer; normal fibroblasts; tumor microenvironment; lung cancer ... See more keywords

Abstract 5840: Normal fibroblasts, cancer-associated fibroblasts, and their senescent counterparts exert varying effects on tumorigenic potential and ABT-263 sensitivity of gastric cancer cells

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5840

Abstract: It has become increasingly apparent that cancer is not a tumor cell-centric disease. Elements of the tumor microenvironment (TME), including fibroblasts and senescent cells, have been shown to contribute to tumor cell proliferation, metastasis, and… read more here.

Keywords: abt 263; sensitivity; ags cells; fibroblasts senescent ... See more keywords
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RNA-sequencing demonstrates transcriptional differences between human vocal fold fibroblasts and myofibroblasts

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recommendations! Published in 2025 at "BMC Genomics"

DOI: 10.1186/s12864-025-11533-w

Abstract: Differentiation of fibroblasts into myofibroblasts is necessary for wound healing, but excessive myofibroblast presence and persistence can result in scarring. Treatment for scarring is limited largely due to a lack of comprehensive understanding of how… read more here.

Keywords: normal fibroblasts; fibroblasts myofibroblasts; cell; vocal fold ... See more keywords

Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts

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recommendations! Published in 2024 at "AntiCancer Research"

DOI: 10.21873/anticanres.16886

Abstract: Background/Aim: The aim of the present study was to determine the synergy of recombinant methioninase (rMETase) and the anti-tubulin agent eribulin on fibrosarcoma cells, in comparison to normal fibroblasts, in vitro. Materials and Methods: HT1080… read more here.

Keywords: normal fibroblasts; fibrosarcoma cells; eribulin; rmetase ... See more keywords

Combinations of Salmonella typhimurium A1-R, Recombinant Methioninase, and Chloroquine, Each Targeting Fundamental Cancer Hallmarks, Are Selectively Effective on Colon Cancer Cells Compared to Normal Fibroblasts

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recommendations! Published in 2025 at "AntiCancer Research"

DOI: 10.21873/anticanres.17729

Abstract: Background/Aim: Metastatic colon cancer is a recalcitrant disease. Previous studies have shown efficacy of Salmonella typhimurium A1-R (A1-R), recombinant methioninase (rMETase), and chloroquine (CQ) on cancer cells as they target fundamental hallmarks of cancer. The… read more here.

Keywords: cancer; cancer cells; cells compared; normal fibroblasts ... See more keywords

Expression of EMT-Related Genes in Hybrid E/M Colorectal Cancer Cells Determines Fibroblast Activation and Collagen Remodeling

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21218119

Abstract: Collagen, the main non-cellular component of the extracellular matrix (ECM), is profoundly reorganized during tumorigenesis and has a strong impact on tumor behavior. The main source of collagen in tumors is cancer-associated fibroblasts. Cancer cells… read more here.

Keywords: normal fibroblasts; colorectal cancer; collagen remodeling; cancer cells ... See more keywords

TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.69178

Abstract: Tumor necrosis factor α stimulated gene 6 (TSG-6), a 30-KD secretory protein, plays an essential role in modulating inflammatory responses and extracellular matrix remodeling. However, little is known regarding the role of TSG-6 in human… read more here.

Keywords: cancer; normal fibroblasts; pro metastatic; tsg ... See more keywords