Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients
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DOI: 10.1007/s00277-021-04550-8
Abstract: Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndrome (MDS) patients. However, more than 50% of low-risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged… read more here.
Keywords: undetectable karyotype; karyotype; normal karyotype; multiplex ligation ... See more keywords
Therapy‐related myeloid neoplasms with normal karyotype show distinct genomic and clinical characteristics compared to their counterparts with abnormal karyotype
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18154
Abstract: Therapy‐related myeloid neoplasms (t‐MNs) are a complication of treatment with cytotoxic chemotherapy and/or radiation therapy. The majority of t‐MNs show chromosomal abnormalities associated with myelodysplastic syndrome (MDS) or KMT2A rearrangements and are characterized by poor… read more here.
Keywords: normal karyotype; related myeloid; mns; therapy ... See more keywords
IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia
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DOI: 10.1186/s40364-025-00769-z
Abstract: Surface antigens of potential clinical significance remain under-characterized in AML. The European Leukemia Network classifies normal karyotype AML (NK-AML) mutated for NPM1 (NPM1c) as a distinct entity associated with favorable outcomes if not associated with… read more here.
Keywords: normal karyotype; triple mutated; aml; nkt aml ... See more keywords
Assessment of a new genomic classification system in acute myeloid leukemia with a normal karyotype
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DOI: 10.18632/oncotarget.23575
Abstract: This study was performed to assess if a recently recommended genomic classification is predictive in patients with normal-karyotype (NK) acute myeloid leukemia (AML). A total of 393 patients were included. Analysis of genetic mutations was… read more here.
Keywords: classification; myeloid leukemia; acute myeloid; normal karyotype ... See more keywords
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia
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DOI: 10.3343/alm.2021.41.4.409
Abstract: Phospholipase C beta 2 (PLC-β2) regulates various essential functions in cell signaling, differentiation, growth, and mobility. We investigated the clinical implications of PLC-β2 protein expression in newly diagnosed normal karyotype acute myeloid leukemia (NK-AML). The… read more here.
Keywords: overexpression; newly diagnosed; phospholipase beta; diagnosed normal ... See more keywords
High Throughput Molecular Characterization of Normal Karyotype Acute Myeloid Leukemia in the Context of the Prospective Trial 02/06 of the Northern Italy Leukemia Group (NILG)
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DOI: 10.3390/cancers12082242
Abstract: By way of a Next-Generation Sequencing NGS high throughput approach, we defined the mutational profile in a cohort of 221 normal karyotype acute myeloid leukemia (NK-AML) enrolled into a prospective randomized clinical trial, designed to… read more here.
Keywords: normal karyotype; acute myeloid; flt3 itd; karyotype acute ... See more keywords
Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing
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DOI: 10.3390/cancers15051386
Abstract: Simple Summary The characterisation of normal-karyotype acute myeloid leukaemia (AML-NK) requires further refinement based on genetic variations. In this study, we ascertained genomic biomarkers via DNA and RNA sequencing in eight AML-NK patients during diagnosis… read more here.
Keywords: normal karyotype; acute myeloid; myeloid leukaemia; gene ... See more keywords
Investigation of Biomarkers Associated with Low Platelet Counts in Normal Karyotype Acute Myeloid Leukemia
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DOI: 10.3390/ijms23147772
Abstract: Acute myeloid leukemia (AML) patients are at risk of bleeding due to disease-related lack of platelets and systemic coagulopathy. Platelets play a role in hemostasis. Leukemic blasts have been shown to alter platelet activation in… read more here.
Keywords: normal karyotype; myeloid leukemia; biomarkers associated; acute myeloid ... See more keywords