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Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04550-8
Abstract: Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndrome (MDS) patients. However, more than 50% of low-risk MDS patients harbor a normal karyotype. Recently, multiplex ligation-dependent probe amplification (MLPA) has emerged…
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Keywords:
undetectable karyotype;
karyotype;
normal karyotype;
multiplex ligation ... See more keywords
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Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18154
Abstract: Therapy‐related myeloid neoplasms (t‐MNs) are a complication of treatment with cytotoxic chemotherapy and/or radiation therapy. The majority of t‐MNs show chromosomal abnormalities associated with myelodysplastic syndrome (MDS) or KMT2A rearrangements and are characterized by poor…
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Keywords:
normal karyotype;
related myeloid;
mns;
therapy ... See more keywords
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Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23575
Abstract: This study was performed to assess if a recently recommended genomic classification is predictive in patients with normal-karyotype (NK) acute myeloid leukemia (AML). A total of 393 patients were included. Analysis of genetic mutations was…
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Keywords:
classification;
myeloid leukemia;
acute myeloid;
normal karyotype ... See more keywords
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Published in 2021 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2021.41.4.409
Abstract: Phospholipase C beta 2 (PLC-β2) regulates various essential functions in cell signaling, differentiation, growth, and mobility. We investigated the clinical implications of PLC-β2 protein expression in newly diagnosed normal karyotype acute myeloid leukemia (NK-AML). The…
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Keywords:
overexpression;
newly diagnosed;
phospholipase beta;
diagnosed normal ... See more keywords
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Published in 2020 at "Cancers"
DOI: 10.3390/cancers12082242
Abstract: By way of a Next-Generation Sequencing NGS high throughput approach, we defined the mutational profile in a cohort of 221 normal karyotype acute myeloid leukemia (NK-AML) enrolled into a prospective randomized clinical trial, designed to…
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Keywords:
normal karyotype;
acute myeloid;
flt3 itd;
karyotype acute ... See more keywords
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Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051386
Abstract: Simple Summary The characterisation of normal-karyotype acute myeloid leukaemia (AML-NK) requires further refinement based on genetic variations. In this study, we ascertained genomic biomarkers via DNA and RNA sequencing in eight AML-NK patients during diagnosis…
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Keywords:
normal karyotype;
acute myeloid;
myeloid leukaemia;
gene ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147772
Abstract: Acute myeloid leukemia (AML) patients are at risk of bleeding due to disease-related lack of platelets and systemic coagulopathy. Platelets play a role in hemostasis. Leukemic blasts have been shown to alter platelet activation in…
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Keywords:
normal karyotype;
myeloid leukemia;
biomarkers associated;
acute myeloid ... See more keywords