13PCharacterizing the DNA damage response in putative stem cells of resected normal lung and matched NSCLC patient samples
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DOI: 10.1093/annonc/mdx090.013
Abstract: Background More than 80% of lung tumors are non-small cell lung cancers (NSCLC). Tumor initiation and propagation are mediated by tumor initiating cells (TICs). In NSCLC and glioblastoma, TICs are characterized by high glycine decarboxylase… read more here.
Keywords: epcam gldc; dna damage; normal lung; lung ... See more keywords
Abstract 6524: Single-cell transcriptomic analysis reveals immune landscape in the malignant transformation of normal lung to lung adenocarcinoma in genetic murine models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6524
Abstract: Background: Our understanding of the initiation and progression of lung precancers is rudimentary, which has impeded advance for lung cancer prevention and interception. Although human specimens are the gold standard to study human cancer biology,… read more here.
Keywords: normal lung; lung adenocarcinoma; lung; single cell ... See more keywords
Comorbidity between lung cancer and COVID-19 pneumonia: role of immunoregulatory gene transcripts in high ACE2-expressing normal lung
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DOI: 10.1177/17588359221133893
Abstract: Background: SARS-CoV-2 (COVID-19) elicits a T-cell antigen-mediated immune response of variable efficacy. To understand this variability, we explored transcriptomic expression of angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) and of immunoregulatory genes in normal lung… read more here.
Keywords: normal lung; high ace2; expression; lung ... See more keywords
Expiratory reactance abnormalities in patients with expiratory dynamic airway collapse: a new application of impulse oscillometry
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DOI: 10.1183/23120541.00080-2018
Abstract: Expiratory dynamic airways collapse (EDAC) is a condition that affects the central airways; it is not well characterised physiologically, with relatively few studies. We sought to characterise impulse oscillometry (IOS) features of EDAC in patients… read more here.
Keywords: normal lung; collapse; reactance; expiratory dynamic ... See more keywords
A Volumetric Computed Tomography Analysis of the Normal Lung in Idiopathic Pulmonary Fibrosis: The Relationship with the Survival
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DOI: 10.2169/internalmedicine.9508-17
Abstract: Objective An image analysis of high-resolution computed tomography (HRCT) can provide objective quantitation of the disease status in idiopathic pulmonary fibrosis (IPF). However, to our knowledge, no reports have investigated the utility of the normal… read more here.
Keywords: computed tomography; normal lung; idiopathic pulmonary; analysis ... See more keywords