APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults
Sign Up to like & getrecommendations! Published in 2021 at "Hippocampus"
DOI: 10.1002/hipo.23327
Abstract: Pattern separation, the ability to differentiate new information from previously experienced similar information, is highly sensitive to hippocampal structure and function and declines with age. Functional MRI studies have demonstrated hippocampal hyperactivation in older adults… read more here.
Keywords: blood flow; normal older; pattern separation; separation ... See more keywords
Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.
Sign Up to like & getrecommendations! Published in 2021 at "Brain imaging and behavior"
DOI: 10.1007/s11682-020-00440-1
Abstract: We investigated whether clinically normal older adults with remote, mild traumatic brain injury (mTBI) show evidence of higher cortical Aβ burden. Our study included 134 clinically normal older adults (age 74.1 ± 6.8 years, 59.7% female, 85.8%… read more here.
Keywords: remote mtbi; brain; burden; clinically normal ... See more keywords
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.01.010
Abstract: CNS inflammation is a key factor in Alzheimer's Disease (AD), but its relation to pathological Aβ, tau, and APOE4 is poorly understood, particularly prior to the onset of cognitive symptoms. To better characterize early relationships… read more here.
Keywords: tau; neuroinflammation; cognitively normal; pathology ... See more keywords
Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2016.12.011
Abstract: Given the converging pathologic and epidemiologic data indicating a relationship between retinal integrity and neurodegeneration, including Alzheimer's disease (AD), we aimed to determine if retinal structure correlates with medial temporal lobe (MTL) structure and function… read more here.
Keywords: retinal structure; neurologically normal; medial temporal; older adults ... See more keywords
Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.12.014
Abstract: The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population. In our study, a total of 106 cognitively normal older subjects… read more here.
Keywords: high degree; cognitively normal; epvs; degree ... See more keywords
Visual paired associate learning deficits associated with elevated beta-amyloid in cognitively normal older adults.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychology"
DOI: 10.1037/neu0000561
Abstract: OBJECTIVE Previous studies have shown that paired associate learning (PAL), a type of episodic memory, is impaired in early Alzheimer's disease (AD). Such tasks require that a set of associations (e.g., pattern-location) be learned over… read more here.
Keywords: paired associate; time; cognitively normal; associate learning ... See more keywords
Impact of Amyloid Burden on Regional Functional Synchronization in the Cognitively Normal Older Adults
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15001-8
Abstract: Previous studies have shown aberrant functional connectivity in preclinical Alzheimer’s disease (AD). However, the effects of beta-amyloid (Aβ) retention on regional functional synchronization in cognitively normal older adults still remain unclear. The aim of this… read more here.
Keywords: functional synchronization; cognitively normal; regional functional; older adults ... See more keywords
Peripheral Insulin Resistance in Cognitively Normal Older Adults Relates to Poorer Performance on a Test for Speed of Processing
Sign Up to like & getrecommendations! Published in 2020 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzaa040_076
Abstract: Peripheral insulin resistance (IR) and impaired glucose metabolism increases the risk for cognitive decline. However, data looking at peripheral IR's relationship with cognition in cognitively normal adults is limited. This study aimed to assess the… read more here.
Keywords: test; cognitively normal; sop; insulin resistance ... See more keywords
Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2020.00190
Abstract: Objective To examine whether osteoarthritis (OA) is associated with a change in adjusted hippocampal volumes (HpVR: hippocampal/intracranial volume × 103) over time among cognitively normal older people. Methods We examined the cross-sectional and longitudinal associations… read more here.
Keywords: older people; osteoarthritis associated; among individuals; hippocampal volumes ... See more keywords
The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.771214
Abstract: Previous studies have indicated that physical activity may be beneficial in reducing the risk for Alzheimer's disease (AD), although the underlying mechanisms are not fully understood. The goal of this study was to evaluate the… read more here.
Keywords: cognitively normal; older adults; activity; normal older ... See more keywords