An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve‐agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.425
Abstract: ABSTRACT We have recently shown that the pyridinium aldoximes, best‐known as therapeutic antidotes for chemical warfare nerve‐agents, could markedly detoxify the carcinogenic tetrachloro‐1,4‐benzoquinone (TCBQ) via an unusual double Beckmann fragmentation mechanism. However, it is still… read more here.
Keywords: radical homolysis; tcbq; iminyl radical; normal physiological ... See more keywords
The function of multidrug resistance-associated protein 3 in the transport of bile acids under normal physiological and lithocholic acid-induced cholestasis conditions.
Sign Up to like & getrecommendations! Published in 2021 at "Current drug metabolism"
DOI: 10.2174/1389200222666210118101715
Abstract: BACKGROUND The role of multidrug resistance-associated protein 3 (Mrp3) in the transport of bile acid (BA) in drug-induced cholestasis have not been well studied. OBJECTIVE In this study, wild type and Mrp3 knockout (Mrp3-/- )… read more here.
Keywords: normal physiological; bile acids; mrp3; transport bile ... See more keywords