Cooperative inhibitory effects of uremic toxins and other serum components on OATP1B1-mediated transport of SN-38
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3276-y
Abstract: PurposeHalf-life of SN-38, an active metabolite of irinotecan, remarkably increases in patients with end-stage kidney disease (ESKD), even though SN-38 is excreted in bile. Uremic toxins (UTs), which accumulate in the serum of ESKD patients,… read more here.
Keywords: serum residue; mediated transport; serum; serum components ... See more keywords
Transcobalamin deficiency: vitamin B12 deficiency with normal serum B12 levels
Sign Up to like & getrecommendations! Published in 2019 at "BMJ Case Reports"
DOI: 10.1136/bcr-2019-232319
Abstract: Transcobalamin (TC) deficiency is a rare autosomal recessive inborn error of cobalamin transport which clinically manifests in early infancy. We describe a child with TC deficiency who presented with classical clinical and lab stigmata of… read more here.
Keywords: serum b12; vitamin b12; normal serum; deficiency ... See more keywords
Syncope With Unusual Wide Complex Arrhythmia in a Young Woman.
Sign Up to like & getrecommendations! Published in 2018 at "Circulation"
DOI: 10.1161/circulationaha.118.037346
Abstract: A 25-year-old woman was admitted after a witnessed syncopal event at home. She reported feeling fatigued in the days before the event. She denied any palpitations, chest pain, seizure aura, or other symptoms immediately preceding… read more here.
Keywords: wide complex; complex arrhythmia; syncope unusual; woman ... See more keywords