Stereotactic body radiotherapy optimization to reduce the risk of carotid blowout syndrome using normal tissue complication probability objectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13563
Abstract: Abstract Purpose To determine the possibility of further improving clinical stereotactic body radiotherapy (SBRT) plans using normal tissue complication probability (NTCP) objectives in order to minimize the risk for carotid blowout syndrome (CBOS). Methods 10… read more here.
Keywords: tissue complication; risk; carotid; normal tissue ... See more keywords
Switchable ROS Scavenger/Generator for MRI‐Guided Anti‐Inflammation and Anti‐Tumor Therapy with Enhanced Therapeutic Efficacy and Reduced Side Effects
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202043
Abstract: Photosensitizer in photodynamic therapy (PDT) accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application. Herein, an intelligent nanoplatform is reported that selectively… read more here.
Keywords: scavenger generator; ros scavenger; normal tissue; tumor ... See more keywords
Technical Note: Non-Invasive monitoring of normal tissue radiation damage using spectral quantitative ultrasound spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.16184
Abstract: BACKGROUND While radiation therapy (RT) is a critical component of breast cancer therapy and is known to decrease overall local recurrence rates, recent studies have shown that normal tissue radiation damage may increase recurrence risk.… read more here.
Keywords: spectroscopy; normal tissue; radiation damage; radiation ... See more keywords
Modeling clinical outcomes in radiotherapy: NTCP, TCP and the "TECs".
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16274
Abstract: Radiation therapy is a double-edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely… read more here.
Keywords: clinical outcomes; effects clinic; outcomes radiotherapy; normal tissue ... See more keywords
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.11.037
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is thought to promote cancer cell survival and confounds attempts… read more here.
Keywords: pdac; mechanical properties; kpa; normal tissue ... See more keywords
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.022
Abstract: The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development.… read more here.
Keywords: rhoa; disease; fret biosensor; normal tissue ... See more keywords
Stricter Postoperative Oropharyngeal Cancer Radiotherapy Normal Tissue Dose Constraints Are Feasible: Stricter Postoperative Oropharyngeal Radiotherapy Constraints.
Sign Up to like & getrecommendations! Published in 2022 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2022.03.006
Abstract: PURPOSE While dose de-escalation is one proposed strategy to mitigate long term toxicity in human papillomavirus associated oropharyngeal cancer, applying more stringent normal tissue constraints may be a complementary approach to further reduce toxicity. Our… read more here.
Keywords: cancer; stricter postoperative; oropharyngeal cancer; normal tissue ... See more keywords
Mean heart dose-based normal tissue complication probability model for pericardial effusion: a study in oesophageal cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97605-9
Abstract: We investigated the normal tissue complication probability (NTCP) of the incidence of pericardial effusion (PCE) based on the mean heart dose (MHD) in patients with oesophageal cancer treated with definitive chemoradiotherapy. The incidences of PCE… read more here.
Keywords: tissue complication; pce; model; complication probability ... See more keywords
A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Radiation Research"
DOI: 10.1101/2022.05.19.492439
Abstract: Radiotherapy of head and neck cancer is known to cause both early and late-occurring toxicities. To better appraise normal tissue responses and their dependence on treatment parameters such as radiation field and type, as well… read more here.
Keywords: preclinical model; normal tissue; head neck; tissue ... See more keywords
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/3010342
Abstract: Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it may cause damage to healthy tissue, with both short-term and long-term side effects. Severe radiation-induced normal tissue damage (RINTD) frequently has… read more here.
Keywords: induced normal; radiation induced; tissue; normal tissue ... See more keywords
Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-0011
Abstract: As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as they are unfit for major surgery. Therefore, there is an urgent need to find radiosensitizing agents… read more here.
Keywords: bladder; tissue; toxicity; normal tissue ... See more keywords