Stereotactic body radiotherapy optimization to reduce the risk of carotid blowout syndrome using normal tissue complication probability objectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13563
Abstract: Abstract Purpose To determine the possibility of further improving clinical stereotactic body radiotherapy (SBRT) plans using normal tissue complication probability (NTCP) objectives in order to minimize the risk for carotid blowout syndrome (CBOS). Methods 10… read more here.
Keywords: tissue complication; risk; carotid; normal tissue ... See more keywords
Switchable ROS Scavenger/Generator for MRI‐Guided Anti‐Inflammation and Anti‐Tumor Therapy with Enhanced Therapeutic Efficacy and Reduced Side Effects
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202043
Abstract: Photosensitizer in photodynamic therapy (PDT) accumulates in both tumor and adjacent normal tissue due to low selective biodistribution, results in undesirable side effect with limited clinic application. Herein, an intelligent nanoplatform is reported that selectively… read more here.
Keywords: scavenger generator; ros scavenger; normal tissue; tumor ... See more keywords
Technical Note: Non-Invasive monitoring of normal tissue radiation damage using spectral quantitative ultrasound spectroscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.16184
Abstract: BACKGROUND While radiation therapy (RT) is a critical component of breast cancer therapy and is known to decrease overall local recurrence rates, recent studies have shown that normal tissue radiation damage may increase recurrence risk.… read more here.
Keywords: spectroscopy; normal tissue; radiation damage; radiation ... See more keywords
Modeling clinical outcomes in radiotherapy: NTCP, TCP and the "TECs".
Sign Up to like & getrecommendations! Published in 2023 at "Medical physics"
DOI: 10.1002/mp.16274
Abstract: Radiation therapy is a double-edged sword which damages both tumor and normal cells. Achieving treatments with high tumor control probability (TCP) yet low normal tissue complication probability (NTCP) is often a struggle because we rarely… read more here.
Keywords: clinical outcomes; effects clinic; outcomes radiotherapy; normal tissue ... See more keywords
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.11.037
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is thought to promote cancer cell survival and confounds attempts… read more here.
Keywords: pdac; mechanical properties; kpa; normal tissue ... See more keywords
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.022
Abstract: The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development.… read more here.
Keywords: rhoa; disease; fret biosensor; normal tissue ... See more keywords
Stricter Postoperative Oropharyngeal Cancer Radiotherapy Normal Tissue Dose Constraints Are Feasible: Stricter Postoperative Oropharyngeal Radiotherapy Constraints.
Sign Up to like & getrecommendations! Published in 2022 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2022.03.006
Abstract: PURPOSE While dose de-escalation is one proposed strategy to mitigate long term toxicity in human papillomavirus associated oropharyngeal cancer, applying more stringent normal tissue constraints may be a complementary approach to further reduce toxicity. Our… read more here.
Keywords: cancer; stricter postoperative; oropharyngeal cancer; normal tissue ... See more keywords
Mean heart dose-based normal tissue complication probability model for pericardial effusion: a study in oesophageal cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-97605-9
Abstract: We investigated the normal tissue complication probability (NTCP) of the incidence of pericardial effusion (PCE) based on the mean heart dose (MHD) in patients with oesophageal cancer treated with definitive chemoradiotherapy. The incidences of PCE… read more here.
Keywords: tissue complication; pce; model; complication probability ... See more keywords
Normal tissue transcriptional signatures for tumor-type-agnostic phenotype prediction
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-76625-1
Abstract: Cancer transcriptional patterns reflect both unique features and shared hallmarks across diverse cancer types, but whether differences in these patterns are sufficient to characterize the full breadth of tumor phenotype heterogeneity remains an open question.… read more here.
Keywords: tissue transcriptional; cancer; normal tissue; tissue ... See more keywords
Antioxidant flavonoid baicalein as a dual purpose radiomodifier with promising bench to bedside potential.
Sign Up to like & getrecommendations! Published in 2025 at "Free radical research"
DOI: 10.1080/10715762.2025.2568922
Abstract: Abstract Despite the potential of drug–radiotherapy combinations, a limited number of oncology drugs are approved by FDA for use along with radiotherapy. Currently, there is no agent available in the clinic that can exhibit dual… read more here.
Keywords: baicalein; antioxidant flavonoid; radiation; radiation exposure ... See more keywords
Successful targeting of multidrug-resistant tumors with bispecific antibodies
Sign Up to like & getrecommendations! Published in 2025 at "mAbs"
DOI: 10.1080/19420862.2025.2492238
Abstract: ABSTRACT Multidrug resistance (MDR) hinders efficacious cancer chemotherapy. Overexpression of the P-glycoprotein (P-gp) efflux pump (EP) on cancer cells is a primary cause of MDR since it expels numerous anticancer drugs. Small molecule intracellular P-gp… read more here.
Keywords: normal tissue; multidrug; tumor; mdr ... See more keywords