Transcriptomic data in tumor-adjacent normal tissues harbor prognostic information on multiple cancer types.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5864
Abstract: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus,… read more here.
Keywords: adjacent normal; tumor adjacent; normal tissues; data tumor ... See more keywords
[Stereotactic body radiotherapy. How to better protect normal tissues?]
Sign Up to like & getrecommendations! Published in 2019 at "Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique"
DOI: 10.1016/j.canrad.2019.07.153
Abstract: The use of stereotactic body radiotherapy (SBRT) has increased rapidly over the past decade. Optimal preservation of normal tissues is a major issue because of their high sensitivity to high doses per session. Extreme hypofractionation… read more here.
Keywords: normal tissues; radiotherapy better; better protect; body radiotherapy ... See more keywords
Vibrational spectra calculation of squamous cell carcinoma in the amide band region
Sign Up to like & getrecommendations! Published in 2018 at "Vibrational Spectroscopy"
DOI: 10.1016/j.vibspec.2018.06.007
Abstract: Abstract Alterations in the amide (1500–1700 cm−1) spectral region probed by Fourier-transform infrared spectroscopy (FTIR) have been reported comparing tumor and normal tissues. Usually, bands in this range are assigned to the so-called Amide I, II,… read more here.
Keywords: normal tissues; cell carcinoma; squamous cell; spectroscopy ... See more keywords
Pan-cancer analysis of the metabolic reaction network.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.09.006
Abstract: Metabolic reprogramming is considered a hallmark of malignant transformation. However, it is not clear whether the network of metabolic reactions expressed by cancers of different origin differ from each other nor from normal human tissues.… read more here.
Keywords: normal tissues; pan cancer; network; cancer analysis ... See more keywords
Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29861-1
Abstract: Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To resolve this paradox, we explained… read more here.
Keywords: normal tissues; epigenomic features; cancer; gene ... See more keywords
Expression of the POTE gene family in human ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35567-1
Abstract: The POTE family includes 14 genes in three phylogenetic groups. We determined POTE mRNA expression in normal tissues, epithelial ovarian and high-grade serous ovarian cancer (EOC, HGSC), and pan-cancer, and determined the relationship of POTE… read more here.
Keywords: normal tissues; group; family; expression ... See more keywords
The role of HOPX in normal tissues and tumor progression
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20191953
Abstract: Abstract The homeodomain-only protein homeobox (HOPX) as the smallest homeodomain protein, lacks certain conserved residues required for DNA binding. Through our literature search, we reviewed the current understandings of HOPX in normal tissues and tumor… read more here.
Keywords: tumor progression; tissues tumor; normal tissues; hopx ... See more keywords
A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123241119
Abstract: Significance “Rare somatic mutations” are present in a small fraction of DNA molecules at as low as one in 107 to 108 bp in normal tissues, and are extremely difficult to detect. EcoSeq was developed… read more here.
Keywords: method somatic; normal tissues; mutations normal; quantification method ... See more keywords
Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000707
Abstract: Transporters on the plasma membrane of tumor cells are promising molecular “Trojan horses” to deliver drugs and imaging agents into cancer cells. Radioiodine-labeled meta-iodobenzylguanidine (mIBG) is used as a diagnostic agent (123I-mIBG) and a targeted… read more here.
Keywords: disposition; meta iodobenzylguanidine; normal tissues; mibg ... See more keywords
Somatic mosaicism in normal tissues
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.364.6444.966-j
Abstract: Human Genetics Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within the genome. To explore how this genetic diversity in individuals contributes… read more here.
Keywords: science; cancer; normal tissues; somatic mosaicism ... See more keywords
Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar2041
Abstract: Vascular protection using gene therapy can reduce the late toxicities of radiotherapy. Skin protection from radiation goes viral With recent improvements in cancer therapy, an increasing number of people are living as cancer survivors, in… read more here.
Keywords: normal tissues; flap; cancer; therapy ... See more keywords