Octadecyl Gallate and Lipid‐Modified MnSe2 Nanoparticles Enhance Radiosensitivity in Esophageal Squamous Cell Carcinoma and Promote Radioprotection in Normal Tissues
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202311291
Abstract: Radiotherapy, a widely used therapeutic strategy for esophageal squamous cell carcinoma (ESCC), is always limited by radioresistance of tumor tissues and side‐effects on normal tissues. Herein, a signature based on four core genes of cyclic… read more here.
Keywords: normal tissues; esophageal squamous; radiosensitivity; squamous cell ... See more keywords
Transcriptomic data in tumor-adjacent normal tissues harbor prognostic information on multiple cancer types.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.5864
Abstract: In identifying prognostic markers in cancer, the roles of tumor‐adjacent normal tissues are often confined to drawing expression differences between tumor and normal tissues rather than being treated as the main targets of investigations. Thus,… read more here.
Keywords: adjacent normal; tumor adjacent; normal tissues; data tumor ... See more keywords
The Relationship between In Vivo Toxicity and Responsive pH in Transistor‐Like pH‐Sensitive Nanodetergents
Sign Up to like & getrecommendations! Published in 2024 at "Small Methods"
DOI: 10.1002/smtd.202401263
Abstract: Subacidity‐responsive materials (saRMs) have attracted considerable attention for disease‐specific pH‐responsive imaging and therapy. However, the guidance for their pH‐responsive design, aimed at achieving effective responses at lesion sites while minimizing unwanted responses in normal tissues,… read more here.
Keywords: transistor; normal tissues; toxicity; vivo toxicity ... See more keywords
[Stereotactic body radiotherapy. How to better protect normal tissues?]
Sign Up to like & getrecommendations! Published in 2019 at "Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique"
DOI: 10.1016/j.canrad.2019.07.153
Abstract: The use of stereotactic body radiotherapy (SBRT) has increased rapidly over the past decade. Optimal preservation of normal tissues is a major issue because of their high sensitivity to high doses per session. Extreme hypofractionation… read more here.
Keywords: normal tissues; radiotherapy better; better protect; body radiotherapy ... See more keywords
Vibrational spectra calculation of squamous cell carcinoma in the amide band region
Sign Up to like & getrecommendations! Published in 2018 at "Vibrational Spectroscopy"
DOI: 10.1016/j.vibspec.2018.06.007
Abstract: Abstract Alterations in the amide (1500–1700 cm−1) spectral region probed by Fourier-transform infrared spectroscopy (FTIR) have been reported comparing tumor and normal tissues. Usually, bands in this range are assigned to the so-called Amide I, II,… read more here.
Keywords: normal tissues; cell carcinoma; squamous cell; spectroscopy ... See more keywords
Pan-cancer analysis of the metabolic reaction network.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.09.006
Abstract: Metabolic reprogramming is considered a hallmark of malignant transformation. However, it is not clear whether the network of metabolic reactions expressed by cancers of different origin differ from each other nor from normal human tissues.… read more here.
Keywords: normal tissues; pan cancer; network; cancer analysis ... See more keywords
Olink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.4c00728
Abstract: Comprehensive protein profiling in intestinal tissues provides detailed information about the pathogenesis of colorectal cancer (CRC). This study quantified the expression levels of 92 oncology-related proteins in tumors, paired para-carcinoma tissues, and remote normal tissues… read more here.
Keywords: colorectal cancer; normal tissues; profiling intestinal; intestinal tissue ... See more keywords
NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-024-55096-y
Abstract: Strong background interference signals from normal tissues have significantly compromised the sensitive fluorescence imaging of early disease tissues with exogenous probes in vivo, particularly for sensitive fluorescence imaging of early liver disease due to the… read more here.
Keywords: normal tissues; nir excited; fluorescence; imaging early ... See more keywords
Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29861-1
Abstract: Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To resolve this paradox, we explained… read more here.
Keywords: normal tissues; epigenomic features; cancer; gene ... See more keywords
Expression of the POTE gene family in human ovarian cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35567-1
Abstract: The POTE family includes 14 genes in three phylogenetic groups. We determined POTE mRNA expression in normal tissues, epithelial ovarian and high-grade serous ovarian cancer (EOC, HGSC), and pan-cancer, and determined the relationship of POTE… read more here.
Keywords: normal tissues; group; family; expression ... See more keywords
TIPE2 combined with immune cell infiltration predicts prognosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-10449-5
Abstract: The incidence of colorectal cancer has shown an obvious upward trend worldwide. The prognostic prediction of CRC has not been well established. Based on immunohistochemistry staining, the expression and scoring of TIPE2 and CD8, CD20,… read more here.
Keywords: colorectal cancer; cancer; normal tissues; tipe2 combined ... See more keywords