Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers
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DOI: 10.1002/lt.25315
Abstract: Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve… read more here.
Keywords: recovery; perfusion; donor livers; machine perfusion ... See more keywords
O043 Evaluation of minimal factor H therapy administered to kidneys during ex vivo normothermic perfusion as a treatment to improve ischaemia reperfusion injury
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Surgery"
DOI: 10.1093/bjs/znad101.043
Abstract: Complement activation is a key mechanism of Ischaemia reperfusion injury, with the alternative pathway driving damage in particular. The main regulator of the alternative pathway is factor H. We hypothesised that homodimeric mini-factor H (HDM-FH;… read more here.
Keywords: reperfusion injury; normothermic perfusion; hdm; factor ... See more keywords
Ex Vivo Normothermic Perfusion of Human Upper Limbs
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DOI: 10.1097/tp.0000000000004045
Abstract: Background. Ischemia-reperfusion injury remains a primary concern in upper extremity transplantation. Ex vivo normothermic perfusion (EVNP) enables near-physiological organ preservation, avoiding the deleterious effects of hypoxia and cooling. We investigated the effectiveness of human limb… read more here.
Keywords: normothermic perfusion; perfusion human; oxygen saturation; human upper ... See more keywords
Some Like It Hot—A Commentary to Ex Vivo Normothermic Perfusion of Human Upper Limbs
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DOI: 10.1097/tp.0000000000004046
Abstract: T he shortage of suitable donors for vascularized composite allotransplantations (VCAs) is exacerbated by inadequate tissue preservation methods. Revascularization within several hours of procurement is mandatory, dra-matically reducing the geographical radius for donor recruitment. Ex… read more here.
Keywords: normothermic perfusion; commentary vivo; hot commentary; perfusion ... See more keywords
Unraveling metabolism during kidney perfusion using tracer studies, a systematic review.
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DOI: 10.1111/aor.14355
Abstract: BACKGROUND Understanding kidney metabolism during perfusion is vital to further develop the technology as a preservation, viability assessment, and resuscitation platform. We reviewed the evidence on the use of labeled metabolites (tracers) to understand "on-pump"… read more here.
Keywords: metabolism; normothermic perfusion; kidney perfusion; kidney ... See more keywords
Effects of T3 Administration on Ex Vivo Rat Hearts Subjected to Normothermic Perfusion: Therapeutic Implications in Donor Heart Preservation and Repair
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DOI: 10.3389/ti.2023.10742
Abstract: The present study investigated the effects of triiodothyronine (T3) administration in ex vivo model of rat heart normothermic perfusion. T3 is cardioprotective and has the potential to repair the injured myocardium. Isolated hearts were subjected… read more here.
Keywords: normothermic perfusion; subjected normothermic; perfusion; administration vivo ... See more keywords