Clinical validation of Northstar response: A novel methylated ctDNA therapy response monitoring assay in patients with advanced gastrointestinal cancers.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e16000
Abstract: e16000 Background: Circulating tumor DNA (ctDNA) offers a non-invasive method to comprehensively assess tumors. While most assays for therapy response monitoring rely on variant allele frequencies, methylated ctDNA has shown promise. However, accuracy has been… read more here.
Keywords: response monitoring; therapy response; response; northstar response ... See more keywords
Clinical validation of Northstar Response for monitoring mono- and combination immunotherapy efficacy in a multi-cancer cohort.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e14548
Abstract: e14548 Background: Methylated circulating tumor DNA (ctDNA) enables non-invasive, real-time treatment response monitoring compared to conventional imaging. Unlike traditional ctDNA approaches that track specific mutations requiring tissue biopsies, methylation analysis offers enhanced sensitivity by increasing… read more here.
Keywords: cancer; immunotherapy; baseline; response ... See more keywords