Brain response in allergic rhinitis: Profile and proposal
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25159
Abstract: In addition to typical nasal symptoms, patients with allergic rhinitis (AR) will further lead to symptoms related to brain function such as hyposmia, anxiety, depression, cognitive impairment, memory loss, etc., which seriously affect the quality… read more here.
Keywords: brain response; brain; nose brain; mechanism ... See more keywords
An update on the role of nanovehicles in nose-to-brain drug delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.01.005
Abstract: A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are… read more here.
Keywords: nose brain; drug delivery; delivery; role nanovehicles ... See more keywords
Recent advances in carrier mediated nose‐to‐brain delivery of pharmaceutics
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.05.009
Abstract: Graphical abstract Figure. No caption available. Abstract Central nervous system (CNS) disorders (e.g., multiple sclerosis, Alzheimer’s disease, etc.) represent a growing public health issue, primarily due to the increased life expectancy and the aging population.… read more here.
Keywords: nose brain; brain delivery; delivery; recent advances ... See more keywords
Nose-to-brain delivery of disulfiram nanoemulsion in situ gel formulation for glioblastoma targeting therapy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120250
Abstract: Glioblastoma (GBM) is a difficult-to-treat cancer, likely attributed to the blood brain barrier and drug resistance. Nose-to-brain drug delivery is a direct and non-invasive pathway for brain targeting with low systemic toxicity. Disulfiram (DSF) has… read more here.
Keywords: delivery; brain; dsf ineg; nose brain ... See more keywords
A Computational Systems Approach to Rational Design of Nose-to-Brain Delivery of Biopharmaceutics
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b04885
Abstract: In this work, a computational systems approach, comprising models at different time and length scales, is developed to elucidate the fundamental chemical, physical, transport, and biological proces... read more here.
Keywords: nose brain; approach rational; design nose; rational design ... See more keywords
Transferrin-Conjugated Chitosan Nanoparticles for Direct Nose-to-Brain Delivery of Ziprasidone: Pharmacokinetic and Pharmacodynamic Evaluation.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.5c00863
Abstract: Ziprasidone (ZS) exhibits limited central nervous system (CNS) penetration due to the blood-brain barrier (BBB). This study investigated the pharmacokinetics and pharmacodynamics of ZS-loaded nanoparticles (NP) and transferrin-functionalized nanoparticles (Tf-NP) administered intravenously (IV) and intranasally… read more here.
Keywords: brain plasma; transferrin conjugated; brain; conjugated chitosan ... See more keywords
Engineered Commensals as Next-Generation Drug Delivery Agents for Nose-to-Brain Therapeutics in Neurological Disorders.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00874
Abstract: Central nervous system (CNS) disorders such as Alzheimer's diseases, Parkinson's diseases, stroke, and glioma remain among the most challenging to treat, largely due to the restrictive nature of the blood-brain barrier (BBB). In recent years,… read more here.
Keywords: brain; next generation; drug delivery; delivery ... See more keywords
Comparing cefotaxime and ceftriaxone in combating meningitis through nose-to-brain delivery using bio/chemoinformatics tools
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78327-w
Abstract: Bio/chemoinformatics tools can be deployed to compare antimicrobial agents aiming to select an efficient nose-to-brain formulation targeting the meningitis disease by utilizing the differences in the main structural, topological and electronic descriptors of the drugs.… read more here.
Keywords: meningitis; nose brain; bio chemoinformatics; ceftriaxone ... See more keywords
Next-generation lipid nanocarriers for Parkinson's therapy: nose-to-brain innovations and clinical prospects.
Sign Up to like & getrecommendations! Published in 2025 at "Nanoscale"
DOI: 10.1039/d5nr03373j
Abstract: Parkinson's disease (PD) remains one of the most formidable challenges in central nervous system (CNS) drug delivery due to the restrictive blood-brain barrier (BBB) and limited efficacy of current dopaminergic therapies. Lipid-based nanocarriers, including liposomes,… read more here.
Keywords: generation lipid; brain; lipid nanocarriers; next generation ... See more keywords
A comprehensive review on lipid-based nanoparticles via nose to brain targeting as a novel approach
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2024.2404414
Abstract: Abstract The central nervous system (CNS) has been a chief concern for millions of people worldwide, and many therapeutic medications are unable to penetrate the blood-brain barrier. Advancements in nanotechnology have enabled safe, effective, and… read more here.
Keywords: based nanoparticles; brain; lipid based; brain targeting ... See more keywords
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2104405
Abstract: Abstract Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents… read more here.
Keywords: lipidic nanocapsules; post ischemic; nose brain; brain delivery ... See more keywords