Brain response in allergic rhinitis: Profile and proposal
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25159
Abstract: In addition to typical nasal symptoms, patients with allergic rhinitis (AR) will further lead to symptoms related to brain function such as hyposmia, anxiety, depression, cognitive impairment, memory loss, etc., which seriously affect the quality… read more here.
Keywords: brain response; brain; nose brain; mechanism ... See more keywords
An update on the role of nanovehicles in nose-to-brain drug delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.01.005
Abstract: A quantitative analysis has cast doubt over the limited advantages provided by particles for nose-to-brain (NTB) drug delivery. Thus, it is imperative to identify the role of nanovehicles in NTB drug delivery. If nanocarriers are… read more here.
Keywords: nose brain; drug delivery; delivery; role nanovehicles ... See more keywords
Recent advances in carrier mediated nose‐to‐brain delivery of pharmaceutics
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.05.009
Abstract: Graphical abstract Figure. No caption available. Abstract Central nervous system (CNS) disorders (e.g., multiple sclerosis, Alzheimer’s disease, etc.) represent a growing public health issue, primarily due to the increased life expectancy and the aging population.… read more here.
Keywords: nose brain; brain delivery; delivery; recent advances ... See more keywords
Nose-to-brain delivery of disulfiram nanoemulsion in situ gel formulation for glioblastoma targeting therapy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120250
Abstract: Glioblastoma (GBM) is a difficult-to-treat cancer, likely attributed to the blood brain barrier and drug resistance. Nose-to-brain drug delivery is a direct and non-invasive pathway for brain targeting with low systemic toxicity. Disulfiram (DSF) has… read more here.
Keywords: delivery; brain; dsf ineg; nose brain ... See more keywords
A Computational Systems Approach to Rational Design of Nose-to-Brain Delivery of Biopharmaceutics
Sign Up to like & getrecommendations! Published in 2019 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b04885
Abstract: In this work, a computational systems approach, comprising models at different time and length scales, is developed to elucidate the fundamental chemical, physical, transport, and biological proces... read more here.
Keywords: nose brain; approach rational; design nose; rational design ... See more keywords
Comparing cefotaxime and ceftriaxone in combating meningitis through nose-to-brain delivery using bio/chemoinformatics tools
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78327-w
Abstract: Bio/chemoinformatics tools can be deployed to compare antimicrobial agents aiming to select an efficient nose-to-brain formulation targeting the meningitis disease by utilizing the differences in the main structural, topological and electronic descriptors of the drugs.… read more here.
Keywords: meningitis; nose brain; bio chemoinformatics; ceftriaxone ... See more keywords
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2104405
Abstract: Abstract Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents… read more here.
Keywords: lipidic nanocapsules; post ischemic; nose brain; brain delivery ... See more keywords
Nanonized carbamazepine for nose-to-brain delivery: pharmaceutical formulation development
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2023.2177673
Abstract: Abstract Epilepsy is one of the most common neurological disorders in the world. The therapeutic treatment is challenging since conventional drugs have limited efficacy and several side effects that impair patient management. Efforts are being… read more here.
Keywords: cbz ncs; formulation; brain; nose brain ... See more keywords
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2029845
Abstract: ABSTRACT Introduction The irreversible destruction of neurons, progressive loss of memory and cognitive behavior, high cost of therapy, and impact on society, desire a better, effective, and affordable treatment of AD. The nose-to-brain delivery approach… read more here.
Keywords: drug; delivery; brain delivery; nose brain ... See more keywords
Developing and maintaining a nose-to-brain map of odorant identity
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220053
Abstract: Olfactory sensory neurons (OSNs) in the olfactory epithelium of the nose transduce chemical odorant stimuli into electrical signals. These signals are then sent to the OSNs' target structure in the brain, the main olfactory bulb… read more here.
Keywords: map; map odorant; brain; nose brain ... See more keywords
Role of serum albumin as a nanoparticulate carrier for nose‐to‐brain delivery of R‐flurbiprofen: implications for the treatment of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12836
Abstract: R‐flurbiprofen (R‐FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β‐amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further… read more here.
Keywords: nose brain; brain delivery; alzheimer disease; albumin nanoparticulate ... See more keywords