Combined Probe Strategy to Increase the Enzymatic Digestion Rate and Accelerate the Renal Radioactivity Clearance of Peptide Radiotracers.
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DOI: 10.1021/acs.molpharmaceut.2c00051
Abstract: High and sustained renal radioactivity accumulation is a major challenge in peptide-based radionuclide imaging and therapy. However, neutral endopeptidase (NEP)-based enzymatic hydrolysis to release and excrete the radioactive fragments has been proven to be an… read more here.
Keywords: nota mvk; combined probe; peptide; rate ... See more keywords