Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.276
Abstract: Expression of the Notch ligand JAG1 and Notch pathway activation promote poor prognosis, basal-like breast cancer. We have recently shown that the pseudokinase Tribbles homolog 3 (TRB3) regulates JAG1 expression in this malignancy. TRB3 is… read more here.
Keywords: notch; cellular stress; notch activation; activation ... See more keywords
An N-glycan on the C2 domain of JAGGED1 is important for Notch activation
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abo3507
Abstract: The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required for optimal activation of the Notch receptor. Somatic mutations that… read more here.
Keywords: jag1; domain; glycosylation; notch ... See more keywords
Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0186818
Abstract: Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones. Previously, we have shown that the transcription factor HoxA3 prevents blood… read more here.
Keywords: notch activation; blood; hoxa3; blood formation ... See more keywords
Corrigendum: Pathophysiological Changes and the Role of Notch-1 Activation After Decompression in a Compressive Spinal Cord Injury Rat Model
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.665669
Abstract: [This corrects the article DOI: 10.3389/fnins.2021.579431.]. read more here.
Keywords: changes role; corrigendum pathophysiological; role notch; activation decompression ... See more keywords