Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer
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DOI: 10.1371/journal.pone.0208221
Abstract: The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu,… read more here.
Keywords: prognostic value; notch hedgehog; patients endometrial; endometrial cancer ... See more keywords
Self-Renewal and Pluripotency in Osteosarcoma Stem Cells’ Chemoresistance: Notch, Hedgehog, and Wnt/β-Catenin Interplay with Embryonic Markers
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DOI: 10.3390/ijms24098401
Abstract: Osteosarcoma is a highly malignant bone tumor derived from mesenchymal cells that contains self-renewing cancer stem cells (CSCs), which are responsible for tumor progression and chemotherapy resistance. Understanding the signaling pathways that regulate CSC self-renewal… read more here.
Keywords: notch hedgehog; wnt catenin; self renewal; embryonic markers ... See more keywords