Notch inhibition counteracts Paneth cell death in absence of caspase-8
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DOI: 10.1007/s00428-018-2368-3
Abstract: Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly… read more here.
Keywords: paneth cell; inhibition; notch; casp8 int ... See more keywords
In Vitro Evaluation of Clinical Candidates of γ-Secretase Inhibitors: Effects on Notch Inhibition and Promoting Beige Adipogenesis and Mitochondrial Biogenesis.
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DOI: 10.1007/s11095-020-02916-7
Abstract: PURPOSE Inhibition of Notch signaling has been recently demonstrated to promote beige adipocyte biogenesis. However, most γ-secretase inhibitors (GSIs) used to achieve pharmacological inhibition of Notch signaling are at the basic research or preclinical stage,… read more here.
Keywords: secretase inhibitors; inhibition; clinical candidates; notch inhibition ... See more keywords
Notch inhibition enhances graft‐versus‐leukemia while reducing graft‐versus‐host disease
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DOI: 10.1016/j.ejphar.2018.10.004
Abstract: ABSTRACT Graft‐versus host disease (GVHD) remains the most significant complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Dissociation of graft versus‐leukemia (GVL) activity from GVHD has yet to be achieved. In this study, we used… read more here.
Keywords: gvhd; notch inhibition; graft versus; host ... See more keywords
Letter by Wang et al Regarding Article, "Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms".
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.119.043299
Abstract: January 21, 2020 e35 *Drs Wang, Yang, and Bi contributed equally. Daxin Wang, MD* Xinquan Yang, MD* Keying Bi, MD* To the Editor: We read with great interest the recent publication by Magee et al,1… read more here.
Keywords: notch; notch inhibition; wang; transplantation ... See more keywords