Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.078
Abstract: Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate into endocrine cells, they must escape Notch activation to express Neurogenin-3. Here, we find that the transcription factor nuclear factor I/A (NFIA) promotes… read more here.
Keywords: notch ligand; cell; cell fate; nfia ... See more keywords
Establishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2017.07.008
Abstract: The Notch ligand DLL4 has key roles during embryonic development of different tissues, but most of the data comes from animal models. Here we describe the generation and characterization of 2 human Pluripotent Stem Cell… read more here.
Keywords: ligand dll4; notch ligand; control hpsc; hpsc ... See more keywords
Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.15017
Abstract: Delta‐like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and… read more here.
Keywords: like canonical; notch ligand; delta like; notch ... See more keywords
Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01958
Abstract: Understanding and targeting Notch signaling effectively has long been valued in the field of cancer and other immune disorders. Here, we discuss key discoveries at the intersection of Notch signaling, cancer and immunology. While there… read more here.
Keywords: targeting notch; notch ligand; immune responses; ligand ... See more keywords