miR‐139‐5p upregulation alleviated spontaneous recurrent epileptiform discharge‐induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11509
Abstract: Epilepsy was characterized by the occurrence of spontaneous recurrent epileptiform discharges (SREDs) in neurons. Previous studies suggested that microRNA (miR)−139‐5p and the Notch pathway were implicated in epilepsy; however, their interaction remained vague. Rat primary… read more here.
Keywords: mir 139; hippocampal neurons; apoptosis; 139 upregulation ... See more keywords
Pharmacological inhibition of the Notch pathway enhances the efficacy of androgen deprivation therapy for prostate cancer
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DOI: 10.1002/ijc.31346
Abstract: Although androgen deprivation therapy (ADT) is a standard treatment for metastatic prostate cancer, this disease inevitably recurs and progresses to ADT‐resistant stage after this therapy. Accordingly, understanding the mechanism of resistance to ADT and finding… read more here.
Keywords: notch; inhibition notch; notch pathway; therapy ... See more keywords
NOTCH and Esophageal Squamous Cell Carcinoma.
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DOI: 10.1007/978-3-030-55031-8_5
Abstract: Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research on its mechanisms, prevention, and therapy. Recent studies have shown that NOTCH mutations are commonly seen in human ESCC. This chapter summarizes… read more here.
Keywords: cell carcinoma; squamous cell; notch; notch pathway ... See more keywords
Notch pathway in small-cell lung cancer: from preclinical evidence to therapeutic challenges
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00441-3
Abstract: BackgroundSmall-cell lung cancer (SCLC) is an aggressive disease with still limited therapeutic options. Despite being both a chemo- and radiation-sensitive malignancy, SCLC recurrence occurs in most cases and negatively impacts patients’ prognosis. Over the last… read more here.
Keywords: sclc; cell lung; lung cancer; notch pathway ... See more keywords
CASK regulates Notch pathway and functions as a tumor promoter in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108789
Abstract: Calcium/calmodulin-dependent serine protein kinase (CASK), a member of membrane-associated guanylate kinase (MAGUK) super-family, is implicated in regulating cell proliferation, cytoskeletal remodeling, and cell metastasis. Our study aimed to investigate the effect of CASK on the… read more here.
Keywords: cask; pancreatic cancer; notch pathway; expression ... See more keywords
Production and characterization of a novel Delta-like 1 functional unit as a tool for Notch pathway activation and generation of a specific antibody.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.01.008
Abstract: Notch signalling is an evolutionary conserved cell-to-cell communication pathway crucial for development and tissue homeostasis. Abnormal Notch signalling by mutations or deregulated expression of its receptors and/or ligands can lead to cancer making it a… read more here.
Keywords: pathway activation; notch; expression; cancer ... See more keywords
Role of the Notch signaling in cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1310842
Abstract: ABSTRACT Introduction: Cholangiocarcinoma (CCA) is an emerging cancer entity of the liver, associated with poor outcome and characterized by resistance to conventional chemotherapeutic treatments. In the last decade, many signaling pathways associated with CCA development… read more here.
Keywords: notch; role notch; signaling cholangiocarcinoma; notch pathway ... See more keywords
Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cells and development"
DOI: 10.1089/scd.2017.0168
Abstract: Hepatocytes differentiated from human embryonic stem cells (ESCs) could provide a powerful tool for enabling cell-based therapies, studying the mechanisms underlying human liver development and disease, and testing the efficacy and safety of pharmaceuticals. However,… read more here.
Keywords: pathway; differentiation; notch pathway; stem cells ... See more keywords
Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise
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DOI: 10.1111/acel.13387
Abstract: A substantial percentage of late‐life depression patients also have an cognitive impairment, which severely affects the life quality, while the co‐occurring mechanisms are still unclear. Physical exercise can ameliorate both depressive behaviors and cognitive dysfunction,… read more here.
Keywords: depression; cognitive dysfunction; notch pathway; physical exercise ... See more keywords
Primary human monocytes differentiate into M2 macrophages and involve Notch-1 pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2016-0319
Abstract: The current study investigates whether inhibiting the Notch-1 signaling pathway in primary human monocytes enhances M2 macrophage differentiation. We generated a primary human monocyte cell culture model to understand the effect of the Notch-1 signaling… read more here.
Keywords: dapt sirna; human monocytes; inflammatory cytokines; notch pathway ... See more keywords
Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00075.2018
Abstract: Bronchopulmonary dysplasia (BPD) is a chronic lung disease of the neonate characterized by impaired alveolarization and vascular growth. BPD is more common in premature male infants, but the reasons underlying sexually dimorphic outcomes are not… read more here.
Keywords: lung fibroblasts; male female; sex specific; notch pathway ... See more keywords