The Notch-3 receptor: A molecular switch to tumorigenesis?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2017.08.011
Abstract: The Notch pathway is a highly conserved pathway increasingly implicated with the progression of human cancers. Of the four existing receptors associated with the pathway, the deregulation in the expression of the Notch-3 receptor is… read more here.
Keywords: receptor molecular; notch receptor; receptor; switch tumorigenesis ... See more keywords
A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1101/2022.05.09.491117
Abstract: All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the… read more here.
Keywords: notch receptor; ligand; cis inhibition; notch ... See more keywords
E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020224
Abstract: Notch is a developmental receptor, conserved in the evolution of the metazoa, which regulates cell fate proliferation and survival in numerous developmental contexts, and also regulates tissue renewal and repair in adult organisms. Notch is… read more here.
Keywords: notch receptor; ligase regulators; ubiquitin ligase; regulators notch ... See more keywords