Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL‐4‐stimulated THP‐1 and primary human macrophages
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12858
Abstract: Notch signaling and nuclear receptor PPARγ are involved in macrophage polarization, but cross talk between them has not been reported in macrophages. In this study, the effect of Notch signaling on PPARγ in IL‐4‐stimulated human… read more here.
Keywords: ppar; akt; ppar protein; protein stability ... See more keywords
Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700128
Abstract: Notch is a mechanosensitive receptor that requires direct cell–cell contact for its activation. Both the strength and the range of notch signaling depend on the size and geometry of the contact sites between cells. These… read more here.
Keywords: cell polarity; ubiquitin ligase; polarity; notch signaling ... See more keywords
Electroacupuncture reverses endothelial cell death and promotes angiogenesis through the VEGF/Notch signaling pathway after focal cerebral ischemia‐reperfusion injury
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2912
Abstract: Angiogenesis is an important mechanism of recovery from ischemic stroke. Recent studies have found that there is a close relationship between the VEGF/Notch pathway and angiogenesis. It is unknown whether EA can exert a brain… read more here.
Keywords: notch signaling; signaling pathway; vegf; pathway focal ... See more keywords
Notch signaling‐induced cyclin d1 in diabetes ameliorating effects of the isolated polysaccharide from Rosa canina: In vitro and in vivo studies
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3755
Abstract: Notch signaling has a role in the expansion of the pancreas and the pathogenesis of diabetes. Modulation of Notch signaling by natural products seems to pave the way for treating diabetes. This research aimed to… read more here.
Keywords: notch signaling; diabetes ameliorating; isolated polysaccharide; cyclin ... See more keywords
Notch signaling and the emergence of hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.230
Abstract: The hematopoietic stem cell (HSC) is able to give rise to all blood cell lineages in vertebrates. HSCs are generated in the early embryo after two precedent waves of primitive hematopoiesis. Canonical Notch signaling is… read more here.
Keywords: stem cells; signaling emergence; hematopoietic stem; emergence hematopoietic ... See more keywords
Regulation of Notch signaling in the developing Drosophila eye by a T‐box containing transcription factor, Dorsocross
Sign Up to like & getrecommendations! Published in 2018 at "genesis"
DOI: 10.1002/dvg.23251
Abstract: Owing to a multitude of functions, there is barely a tissue or a cellular process that is not being regulated by Notch signaling. To allow the Notch signal to be deployed in numerous contexts, many… read more here.
Keywords: notch; eye discs; genetic interaction; notch signaling ... See more keywords
TGF‐β pro‐oligodendrogenic effects on adult SVZ progenitor cultures and its interaction with the Notch signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23253
Abstract: Adult neural progenitor cells (NPCs) are capable of differentiating into neurons, astrocytes, and oligodendrocytes throughout life. Notch and transforming growth factor β1 (TGF‐β) signaling pathways play critical roles in controlling these cell fate decisions. TGF‐β… read more here.
Keywords: cell; interaction notch; svz; progenitor ... See more keywords
MicroRNA‐34a promotes CMECs apoptosis and upregulate inflammatory cytokines, thus worsening CMECs damage and inhibiting angiogenesis by negatively targeting the Notch signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27433
Abstract: Recently, microRNA‐34a (miR‐34a) has been reported to lead to secretion of proinflammatory cytokine in endothelial cells, whereas whether miR‐34a plays a protective role in damaged cardiac microvascular endothelial cells (CMECs) remains to be determined. Herein,… read more here.
Keywords: angiogenesis; apoptosis; signaling pathway; microrna 34a ... See more keywords
Maintenance of Bone Homeostasis by DLL1‐Mediated Notch Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25647
Abstract: Adult bone mass is maintained through a balance of the activities of osteoblasts and osteoclasts. Although Notch signaling has been shown to maintain bone homeostasis by controlling the commitment, differentiation, and function of cells in… read more here.
Keywords: bone homeostasis; dll1; bone; physiology ... See more keywords
Molecular mechanism of Notch signaling with special emphasis on microRNAs: Implications for glioma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26775
Abstract: Glioma is the most aggressive primary brain tumor and is notorious for resistance to chemoradiotherapy. Although its associated mechanisms are still not completely understood, Notch signaling, an evolutionarily conserved pathway, appears to be the key… read more here.
Keywords: mechanism notch; glioma; signaling special; molecular mechanism ... See more keywords
Notch signaling at the crossroads of innate and adaptive immunity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ri0520-138r
Abstract: Notch signaling is an evolutionarily conserved cell‐to‐cell signaling pathway that regulates cellular differentiation and function across multiple tissue types and developmental stages. In this review, we discuss our current understanding of Notch signaling in mammalian… read more here.
Keywords: notch; innate adaptive; adaptive immunity; notch signaling ... See more keywords