Role of Notch in endothelial biology.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09793-7
Abstract: The Notch signalling pathway is one of the main regulators of endothelial biology. In the last 20 years the critical function of Notch has been uncovered in the context of angiogenesis, participating in tip-stalk specification, arterial-venous… read more here.
Keywords: notch signalling; signalling pathway; role notch; biology ... See more keywords
Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ &agr;&bgr; T‐cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.10.013
Abstract: HighlightsThe Notch activation may be cis or trans ligand‐dependent which are regulated by TCR signalling on human &agr;&bgr; T cells.Notch signalling has the ability to affect both the proximal and distal TCR signalling events.Inhibition of… read more here.
Keywords: notch signalling; agr bgr; bgr cells; tcr signalling ... See more keywords
Notch-out for breast cancer therapies.
Sign Up to like & getrecommendations! Published in 2017 at "New biotechnology"
DOI: 10.1016/j.nbt.2017.08.004
Abstract: Notch signalling is an evolutionarily highly conserved pathway that plays a crucial role during embryonic development and in tissue homeostasis maintenance during adult life. Abnormal Notch signalling has been implicated in several human genetic disorders… read more here.
Keywords: notch signalling; notch breast; notch; breast cancer ... See more keywords
Effects of the Notch signalling pathway on hyperoxia-induced immature brain damage in newborn mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.05.065
Abstract: Hyperoxia exposure can cause dramatic release of proinflammatory cytokines, leading to neuronal apoptosis and inducing white matter damage in newborn mouse brains. Some studies indicated that the Notch activation was provoked during inflammation and might… read more here.
Keywords: notch signalling; hyperoxia; exposure; mice ... See more keywords
Notch signalling in placental development and gestational diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2017.01.117
Abstract: Activation of Notch signalling upon cell-cell contact of neighbouring cells controls a plethora of cellular processes such as stem cell maintenance, cell lineage determination, cell proliferation, and survival. Accumulating evidence suggests that the pathway also… read more here.
Keywords: notch signalling; placental development; gestational diseases; notch ... See more keywords
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation
Sign Up to like & getrecommendations! Published in 2017 at "Nature Cell Biology"
DOI: 10.1038/ncb3555
Abstract: Endothelial sprouting and proliferation are tightly coordinated processes mediating the formation of new blood vessels during physiological and pathological angiogenesis. Endothelial tip cells lead sprouts and are thought to suppress tip-like behaviour in adjacent stalk… read more here.
Keywords: notch signalling; signalling couples; angiogenesis; formation ... See more keywords
Notch as a tumour suppressor
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2016.145
Abstract: The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation… read more here.
Keywords: notch signalling; tumour suppressor; tumour; notch tumour ... See more keywords
Notch and interacting signalling pathways in cardiac development, disease, and regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0100-2
Abstract: Cardiogenesis is a complex developmental process involving multiple overlapping stages of cell fate specification, proliferation, differentiation, and morphogenesis. Precise spatiotemporal coordination between the different cardiogenic processes is ensured by intercellular signalling crosstalk and tissue–tissue interactions.… read more here.
Keywords: notch signalling; heart; signalling pathways; notch ... See more keywords
Notch Signalling Under Maternal-to-Zygotic Transition
Sign Up to like & getrecommendations! Published in 2022 at "Fly"
DOI: 10.1080/19336934.2022.2139981
Abstract: ABSTRACT The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which… read more here.
Keywords: notch signaling; zygotic transition; notch signalling; maternal zygotic ... See more keywords
Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-&agr; in the Inflamed Intestinal Epithelia of IBD Patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjy180
Abstract: BACKGROUND AND AIMS The intestinal epithelium of inflammatory bowel disease [IBD] patients is exposed to various pro-inflammatory cytokines, most notably tumour necrosis factor alpha [TNF-α]. We have previously shown that the Notch signalling pathway is… read more here.
Keywords: notch signalling; signalling tnf; expression; ibd patients ... See more keywords
Notch signalling in healthy and diseased vasculature
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220004
Abstract: Notch signalling is an evolutionarily highly conserved signalling mechanism governing differentiation and regulating homeostasis in many tissues. In this review, we discuss recent advances in our understanding of the roles that Notch signalling plays in… read more here.
Keywords: notch signalling; diseased vasculature; notch; healthy diseased ... See more keywords