Overexpression of c-Myc-dependent heterogeneous nuclear ribonucleoprotein A1 promotes proliferation and inhibits apoptosis in NOTCH1-mutated chronic lymphocytic leukemia cells
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DOI: 10.1097/cm9.0000000000002037
Abstract: Abstract Background: NOTCH1 mutation is an essential molecular biologic aberration in chronic lymphocytic leukemia (CLL). CLL patients with NOTCH1 mutation have shown an unfavorable survival and a poor response to chemoimmunotherapy. This study aims to… read more here.
Keywords: proliferation; notch1 mutation; expression; hnrnpa1 ... See more keywords
NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer
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DOI: 10.3389/fimmu.2022.920253
Abstract: Background Patients with early-stage laryngeal cancer, even stage T1-2N0, are at considerable risk of recurrence and death. The genetic and immunologic characteristics of recurrent laryngeal cancer remain unclear. Methods A total of 52 T1-2N0 laryngeal… read more here.
Keywords: notch1 mutation; laryngeal cancer; cancer; immune response ... See more keywords