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Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2016.67.5264
Abstract: Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a…
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Keywords:
subgroup;
mutations define;
notch1 mutations;
metastasis ... See more keywords
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Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.6089
Abstract: 6089Background: We previously reported that activating NOTCH1 mutations occurs in approximately 20% of ACCs and drive a phenotype with solid histology, liver and bone metastases, poor prognosis, an...
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Keywords:
mutations adenoid;
notch1 mutations;
cystic carcinoma;
association activating ... See more keywords
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Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.746577
Abstract: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of large lymphoid B cell malignancy with distinct clinical and genetic features. Recently, NOTCH1 mutations were identified in DLBCL cases by Next-generation sequencing (NGS), but the…
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Keywords:
notch1 mutations;
cell lymphoma;
clinical features;
cell ... See more keywords
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Published in 2022 at "Cancers"
DOI: 10.3390/cancers14122997
Abstract: Simple Summary Mutations of the NOTCH1 gene are a validated prognostic marker in chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based therapies. At present, the most frequent pathological alteration of the NOTCH1 gene…
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Keywords:
lymphocytic leukemia;
cll;
notch1 mutations;
chronic lymphocytic ... See more keywords
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Published in 2023 at "Journal of Clinical and Experimental Dentistry"
DOI: 10.4317/jced.60293
Abstract: Background On certain occasions, oral cancer is preceded by potentially malignant lesions. The degree of dysplasia in Guinea pigs attempts to determine the risk of developing a malignant lesion. The search for genetic mutations, biomarkers,…
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Keywords:
potentially malignant;
oral cancer;
notch1 mutations;
detection ... See more keywords