Articles with "notch1 mutations" as a keyword



Photo from wikipedia

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

Sign Up to like & get
recommendations!
Published in 2017 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2016.67.5264

Abstract: Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a… read more here.

Keywords: subgroup; mutations define; notch1 mutations; metastasis ... See more keywords
Photo by nci from unsplash

Association of activating NOTCH1 mutations in adenoid cystic carcinoma with shorter progression-free survival to systemic therapy.

Sign Up to like & get
recommendations!
Published in 2017 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2017.35.15_suppl.6089

Abstract: 6089Background: We previously reported that activating NOTCH1 mutations occurs in approximately 20% of ACCs and drive a phenotype with solid histology, liver and bone metastases, poor prognosis, an... read more here.

Keywords: mutations adenoid; notch1 mutations; cystic carcinoma; association activating ... See more keywords
Photo from wikipedia

Clinical Features and Prognostic Significance of NOTCH1 Mutations in Diffuse Large B-Cell Lymphoma

Sign Up to like & get
recommendations!
Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.746577

Abstract: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of large lymphoid B cell malignancy with distinct clinical and genetic features. Recently, NOTCH1 mutations were identified in DLBCL cases by Next-generation sequencing (NGS), but the… read more here.

Keywords: notch1 mutations; cell lymphoma; clinical features; cell ... See more keywords
Photo by nci from unsplash

Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

Sign Up to like & get
recommendations!
Published in 2022 at "Cancers"

DOI: 10.3390/cancers14122997

Abstract: Simple Summary Mutations of the NOTCH1 gene are a validated prognostic marker in chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based therapies. At present, the most frequent pathological alteration of the NOTCH1 gene… read more here.

Keywords: lymphocytic leukemia; cll; notch1 mutations; chronic lymphocytic ... See more keywords
Photo from wikipedia

Detection of NOTCH1 mutations in paraffin samples in patients with potentially malignant lesions

Sign Up to like & get
recommendations!
Published in 2023 at "Journal of Clinical and Experimental Dentistry"

DOI: 10.4317/jced.60293

Abstract: Background On certain occasions, oral cancer is preceded by potentially malignant lesions. The degree of dysplasia in Guinea pigs attempts to determine the risk of developing a malignant lesion. The search for genetic mutations, biomarkers,… read more here.

Keywords: potentially malignant; oral cancer; notch1 mutations; detection ... See more keywords