Targeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia"
DOI: 10.1038/s41375-022-01516-1
Abstract: The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to target this circuit is poorly defined. Bromodomain-containing protein… read more here.
Keywords: cd44 axis; cd44; leukemia; myc cd44 ... See more keywords
Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis
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DOI: 10.1038/s41388-022-02246-5
Abstract: The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC development and progression. Clinically, high Notch1 expression correlates… read more here.
Keywords: liver progenitor; hcc; pulmonary metastasis; vcam1 ... See more keywords