Notch1 and Notch2 Signaling Exclusively but Cooperatively Maintain Fetal Myogenic Progenitors.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac056
Abstract: Myogenic progenitors (MPs) generate myocytes that fuse to form myofibers during skeletal muscle development while maintaining the progenitor pool, which is crucial for generating sufficient muscle. Notch signaling has been known to reserve a population… read more here.
Keywords: notch1 notch2; cooperatively maintain; notch2 signaling; signaling exclusively ... See more keywords
Notch Signaling Suppresses Melanoma Tumor Development in BRAF/Pten Mice
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DOI: 10.3390/cancers15020519
Abstract: Simple Summary It is now well recognized that alterations in both oncogenic and tumor suppressor genes are required for cutaneous melanoma tumorigenesis. Although Notch signaling has been implicated in many aspects of melanoma biology, the… read more here.
Keywords: notch signaling; melanoma; notch1 notch2; mice ... See more keywords
The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
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DOI: 10.7554/elife.40045
Abstract: DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1… read more here.
Keywords: ligand function; function vivo; function; dll1 dll4 ... See more keywords