Far infrared promotes wound healing through activation of Notch1 signaling
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1580-y
Abstract: The Notch signaling pathway is critically involved in cell proliferation, differentiation, development, and homeostasis. Far infrared (FIR) has an effect that promotes wound healing. However, the underlying molecular mechanisms are unclear. In the present study,… read more here.
Keywords: fir; wound healing; notch1 signaling; migration proliferation ... See more keywords
Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.094
Abstract: Human T-cell leukemia virus 1 (HTLV-1), an oncogenic retrovirus, and Notch1 signaling, implicated in tumor formation and progression, are both associated with the development of adult T-cell leukemia (ATL). Here we explored the possibility of… read more here.
Keywords: tax; cell leukemia; notch1 signaling; nicd ... See more keywords
Deubiquitinase inhibitor b‐AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.020
Abstract: Abstract b‐AP15, a potent and selective inhibitor of the ubiquitin‐specific peptidase 14 (USP14), displays in vitro and in vivo antitumor abilities on some types of cancer cells. However, the mechanism underlying its action is not… read more here.
Keywords: hepatocellular carcinoma; notch1 signaling; stress; carcinoma cells ... See more keywords
Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119904
Abstract: AIM Alcohol abuse is a significant causative factor of death worldwide. The Notch1 signaling pathway is involved in alcohol tolerance, withdrawal and dependence. Agomelatine is a known antidepressant acting as a melatonin receptor (MT1/2) agonist… read more here.
Keywords: notch1 signaling; signaling pathway; modulating notch1; withdrawal symptoms ... See more keywords
WITHDRAWN: The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience letters"
DOI: 10.1016/j.neulet.2020.135244
Abstract: Women are vulnerable to adverse stress events, especially during perimenopause. Substantial evidence has associated the impaired neuronal plasticity with abnormal behaviors under stressful conditions in animals. The Notch signaling pathway is critical for neuronal plasticity… read more here.
Keywords: mid aged; notch1 signaling; aged female; signaling pathway ... See more keywords
The involvement of Notch1 signaling pathway in mid-aged female rats under chronic restraint stress
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135313
Abstract: Women are vulnerable to adverse stress events, especially during perimenopause. Substantial evidence has associated the impaired neuronal plasticity with abnormal behaviors under stressful conditions in animals. The Notch signaling pathway is critical for neuronal plasticity… read more here.
Keywords: mid aged; notch1 signaling; aged female; signaling pathway ... See more keywords
Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.07.001
Abstract: Summary The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic… read more here.
Keywords: arterial endothelial; functional arterial; notch1 signaling; hif1 ... See more keywords
Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031670
Abstract: ABSTRACT Sperm-associated antigen 5 (SPAG5) has been identified as a driver in several type of cancers. In this study, we aimed to reveal the role of SPAG5 in melanoma and clarify whether FOXM1 (forkhead box… read more here.
Keywords: spag5; notch1 signaling; cell; sperm associated ... See more keywords
Abstract 3598: Cooperative NF-KappaB and Notch1 signaling promotes a macrophage-mediated metastatic phenotype in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3598
Abstract: Metastasis is a multistep process that leads to the formation of clinically detectable tumor foci at distant organs and, frequently, to patient demise. Only a subpopulation of breast cancer cells within the primary tumor can… read more here.
Keywords: expression; breast cancer; notch1 signaling; tumor ... See more keywords
NOTCH1 Signaling Hijacks the Stress Response to Promote T-ALL.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-133
Abstract: The heat shock transcription factor HSF1 is upregulated in patients with T-ALL. read more here.
Keywords: hijacks stress; signaling hijacks; response promote; notch1 signaling ... See more keywords
Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling
Sign Up to like & getrecommendations! Published in 2018 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000485890
Abstract: Background: Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory… read more here.
Keywords: inhibition notch1; notch1 signaling; dex gsi; th1 th2 ... See more keywords