Notch4 inhibition suppresses invasion and vasculogenic mimicry formation of hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1794-9
Abstract: SummaryVasculogenic mimicry (VM) is a process by which aggressive tumor cells generate non-endothelial cell-lined channels in malignant tumors including hepatocellular carcinoma (HCC). It has provided new insights into tumor behavior and has surfaced as a… read more here.
Keywords: hepatocellular carcinoma; invasion; formation; notch4 inhibition ... See more keywords
Abstract LB009: Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb009
Abstract: The Notch signaling pathway, particularly endothelial Notch signaling, plays a key role in tumor formation and angiogenesis. Inhibiting Notch1 or its ligand, Delta-like ligand 4 (Dll4), can induce hypersprouting of the tumor vasculature and thus… read more here.
Keywords: macrophage recruitment; progression; notch4 inhibition; tumor ... See more keywords