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   Articles with "notochord" as a keyword



Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development

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recommendations! Published in 2017 at "Current Biology"

DOI: 10.1016/j.cub.2017.05.067

Abstract: The embryonic notochord is a flexible structure present during development that serves as scaffold for formation of the vertebrate spine. This rod-like organ is thought to have evolved in non-vertebrate chordates to facilitate locomotion by… read more here.

Keywords: caveolae; mechanical stress; caveolae protect; notochord ... See more keywords

Pinhead antagonizes Admp to promote notochord formation

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.102520

Abstract: Summary Dorsoventral patterning of a vertebrate embryo critically depends on the activity of Smad1 that mediates signaling by BMP proteins, anti-dorsalizing morphogenetic protein (Admp), and their antagonists. Pinhead (Pnhd), a cystine-knot-containing secreted protein, is expressed… read more here.

Keywords: antagonizes admp; admp promote; pinhead antagonizes; notochord ... See more keywords

Tissue-specific expression of carbohydrate sulfotransferases drives keratan sulfate biosynthesis in the notochord and otic vesicles of Xenopus embryos

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recommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2023.957805

Abstract: Keratan sulfate (KS) is a glycosaminoglycan that is enriched in vertebrate cornea, cartilage, and brain. During embryonic development, highly sulfated KS (HSKS) is first detected in the developing notochord and then in otic vesicles; therefore,… read more here.

Keywords: notochord; biosynthesis; expression; otic vesicles ... See more keywords

Matrix metalloproteinase Nas15 regulates the lumen formation and expansion in Ciona notochord

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recommendations! Published in 2024 at "Frontiers in Ecology and Evolution"

DOI: 10.3389/fevo.2024.1385516

Abstract: Lumen formation, as a key process of biological tube construction, is essential in various physiological processes such as nutrient and waste transporting, gas exchanging, and structural supporting. However, the mechanisms underlying tubular lumen development are… read more here.

Keywords: metalloproteinase; notochord; nas15; ciona ... See more keywords

Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network

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recommendations! Published in 2022 at "eLife"

DOI: 10.7554/elife.73992

Abstract: Gene regulatory networks coordinate the formation of organs and structures that compose the evolving body plans of different organisms. We are using a simple chordate model, the Ciona embryo, to investigate the essential gene regulatory… read more here.

Keywords: gene regulatory; notochord; xbp1; regulatory network ... See more keywords