Panax notoginseng saponins suppress lipopolysaccharide‐induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF‐κB inflammatory pathways
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DOI: 10.1002/ptr.6488
Abstract: Dysfunction of the blood‐brain barrier (BBB) is a prerequisite for the pathogenesis of many cerebral diseases. Oxidative stress and inflammation are well‐known factors accounting for BBB injury. Panax notoginseng saponins (PNS), a clinical commonly used… read more here.
Keywords: notoginseng saponins; panax notoginseng; nrf2 antioxidant; adhesion bend ... See more keywords
Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2017.12.011
Abstract: Saponins such as notoginsenosides and ginsenosides from Panax notoginseng are responsible for the herb's clinical applications. Unfortunately, there is poor oral bioavailability of saponins. However, gut microbiota can transform saponins to yield the metabolites that… read more here.
Keywords: dad tof; notoginseng saponins; microbiota; panax notoginseng ... See more keywords
In vivo metabolic profiles of Panax notoginseng saponins mediated by gut microbiota in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c01857
Abstract: Panax notoginseng saponins (PNS) are the major health-beneficial components of P. notoginseng with very low oral bioavailability, which could be bio-transformed by gut microbiota in vitro. However, in vivo biotransformation of PNS mediated by gut… read more here.
Keywords: mediated gut; notoginseng saponins; microbiota; panax notoginseng ... See more keywords
Therapeutic effects of Panax notoginseng saponins in rheumatoid arthritis: network pharmacology and experimental validation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2086379
Abstract: ABSTRACT Panax notoginseng saponins (PNS) have been reported to have good anti-inflammatory effects. However, the anti-inflammatory effect mechanism in rheumatoid arthritis (RA) remains unknown. The focus of this research was to investigate the molecular mechanism… read more here.
Keywords: network; pharmacology; rheumatoid arthritis; pns ... See more keywords
Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice
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DOI: 10.1111/jocd.13042
Abstract: Panax notoginseng saponins are believed to promote wound healing due to its anti‐proliferative effect on fibroblasts. The present work was therefore aimed to examine the beneficial effect of PNS on wound healing in vitro and… read more here.
Keywords: cutaneous wound; wound healing; notoginseng saponins; panax notoginseng ... See more keywords
Panax notoginseng Saponins Regulate Macrophage Polarization under Hyperglycemic Condition via NF-κB Signaling Pathway
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DOI: 10.1155/2018/9239354
Abstract: Panax notoginseng saponins (PNS), the principal constituents derived from Panax notoginseng, have been extensively used for treating cardiocerebral vascular diseases in China and other Asian countries. The main effects of PNS were anti-inflammatory properties, inhibition… read more here.
Keywords: notoginseng saponins; panax notoginseng; macrophage polarization; polarization hyperglycemic ... See more keywords
Analysis of the Renal Protection and Antioxidative Stress Effects of Panax notoginseng Saponins in Diabetic Nephropathy Mice
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DOI: 10.1155/2022/3610935
Abstract: Objective Diabetic nephropathy (DN), a diabetes-induced chronic complication, is the major trigger of end-stage renal disease. As the main active ingredient of Panax notoginseng (PNG), Panax notoginseng saponins (PNS) are crucial in treating renal diseases.… read more here.
Keywords: panax notoginseng; renal protection; mice; notoginseng saponins ... See more keywords
Pharmacological Effect of Panax notoginseng Saponins on Cerebral Ischemia in Animal Models
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DOI: 10.1155/2022/4281483
Abstract: Panax notoginseng saponins (PNS), bioactive compounds, are commonly used to treat ischemic heart and cerebral diseases in China and other Asian countries. Most previous studies of PNS have focused on the mechanisms underlying their treatment… read more here.
Keywords: cerebral ischemia; ischemia; panax notoginseng; notoginseng saponins ... See more keywords
Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats
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DOI: 10.1186/s12906-018-2118-8
Abstract: BackgroundIn China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to antioxidant activity, but… read more here.
Keywords: acute pancreatitis; notoginseng saponins; panax notoginseng; effects panax ... See more keywords
Protective Effect of Panax Notoginseng Saponins on Apolipoprotein-E-deficient Atherosclerosis-prone mice.
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DOI: 10.2174/1381612828666220128104636
Abstract: BACKGROUND It is widely recognized that atherosclerosis（AS）is related to vascular inflammation. Panax notoginseng saponins (PNS) extracted from the roots of Panax notoginseng has been shown to possess anti-inflammatory activity. It is widely used in the… read more here.
Keywords: apoe mice; mice; atherosclerosis; notoginseng saponins ... See more keywords
Lysozyme Improves the Inhibitory Effects of Panax notoginseng Saponins on Phenotype Transformation of Vascular Smooth Muscle Cells by Binding to Ginsenoside Re
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DOI: 10.3389/fnut.2021.795888
Abstract: Panax notoginseng saponins (PNS) have been used to treat cardiovascular diseases for hundreds of years in China. Lysozyme can bind to exogenous compounds and promote their activity. Nevertheless, knowledge of whether there is a synergistic… read more here.
Keywords: vascular smooth; notoginseng saponins; lysozyme; smooth muscle ... See more keywords