OA14 Non-steroidal anti-inflammatory drugs reduce sacroiliac joint inflammation in axial spondyloarthritis
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DOI: 10.1093/rheumatology/kead104.014
Abstract: MRI evidence of active sacroiliitis (sacroiliac joint bone marrow oedema (BMO)) is commonly used to assist diagnosis and classification of axial spondyloarthritis (axSpA). Non-steroidal anti-inflammatory drugs (NSAIDs) are used as first-line therapy, and for persistent… read more here.
Keywords: rheumatology; novartis pfizer; sacroiliac joint; pfizer ... See more keywords
P134 Efficacy of Upadacitinib on Psoriatic Arthritis with Axial Involvement Defined by Investigator Assessment and PRO-Based Criteria: Results from two Phase 3 Studies
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DOI: 10.1093/rheumatology/kead104.175
Abstract: Patients with PsA and axial involvement have higher disease activity and greater reductions in quality of life; however, there are no accepted criteria for identifying axial involvement in PsA. The objective of this post-hoc analysis… read more here.
Keywords: novartis pfizer; investigator assessment; abbvie; axial involvement ... See more keywords
OP0334 Efficacy and safety of continuing versus withdrawing adalimumab (ADA) in maintaining remission in patients with non-radiographic axial spondyloarthritis (NR-AXSPA)
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DOI: 10.1136/annrheumdis-2018-eular.2641
Abstract: Tapering and flaring in PsA and SpA Background It is not known whether TNF blockers can be stopped in nr-axSpA patients (pts) who are in remission. Objectives ABILITY-3, reported here, assessed if ADA can be… read more here.
Keywords: abbvie; ada; pbo; novartis pfizer ... See more keywords
FRI0426 IXEKIZUMAB MAKES REMISSION AND LOW DISEASE ACTIVITY POSSIBLE IN PATIENTS WITH PSORIATIC ARTHRITIS: TWO-YEAR RESULTS IN TNF INADEQUATE RESPONDERS OR BIOLOGIC-NAïVE PATIENTS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.1225
Abstract: Background Psoriatic arthritis (PsA) is a heterogeneous inflammatory disease that can involve peripheral and axial joints, skin, and entheses. A number of validated composite indices have been developed, not only to measure overall disease activity… read more here.
Keywords: pfizer; novartis pfizer; disease; eli lilly ... See more keywords
FRI0429 NON TOPICAL PHARMACOLOGICAL TREATMENT OF EARLY, UNTREATED (DMARD-NAïVE, SYSTEMIC THERAPY-NäIVE) PSORIATIC DISEASE: A SYSTEMATIC REVIEW
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.1837
Abstract: Background Psoriatic disease (PsD) refers to a systemic condition, probably driven by chronic and complex inflammatory mechanisms. PsD patients experience a fickle mixture of cutaneous (nail dystrophy, psoriatic lesions spectrum) and musculoskeletal (MSK: arthritis, enthesitis,… read more here.
Keywords: lilly novartis; celgene; consultant; research ... See more keywords
FRI0437 PATIENT-DEFINED FLARES IN IN PSORIATIC ARTHRITIS: WHAT DO THEY MEAN? AN ANALYSIS OF CHANGE BETWEEN 2 VISITS IN 222 PATIENTS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.2161
Abstract: Background In psoriatic arthritis (PsA), disease fluctuations lead to periods of flares which impact patients’ lives and treatment retention, these flares have been little studied. Objectives To explore the frequency of flares in patients with… read more here.
Keywords: pfizer; novartis pfizer; disease; celgene ... See more keywords
THU0359 WHAT IS THE LEVEL OF AGREEMENT BETWEEN LOCAL AND CENTRAL READERS IN THE DETECTION OF ACTIVE AND STRUCTURAL LESIONS ON MRI TYPICAL OF AXIAL SPONDYLOARTHRITIS? DATA FROM THE ASAS CLASSIFICATION COHORT STUDY
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DOI: 10.1136/annrheumdis-2019-eular.3158
Abstract: Background There has been no central reader evaluation of MRI scans from the ASAS Classification Cohort (ASAS-CC)1 to compare detection of lesions in the sacroiliac joints (SIJ) between central and ASAS-CC local site readers. Active… read more here.
Keywords: pfizer; central readers; novartis pfizer; structural lesions ... See more keywords
THU0358 DEVELOPMENT OF A SET OF ASAS QUALITY STANDARDS FOR ADULTS WITH AXIAL SPONDYLOARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4555
Abstract: Background: There is wide variation in the management of patients with axial spondyloarthritis (axSpA) worldwide with significant unmet needs such as delayed diagnosis. A major goal of the international organization Assessment of SpondyloArthritis international Society… read more here.
Keywords: none declared; pfizer; novartis pfizer; celgene ... See more keywords
OP0109 EFFICACY OF FILGOTINIB VS PLACEBO IN ACTIVE PSORIATIC ARTHRITIS: PATIENT-LEVEL DATA FROM EQUATOR, A RANDOMIZED, PHASE 2 STUDY
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.6064
Abstract: Background Filgotinib (FIL) is an oral, selective Janus kinase 1 inhibitor in development for the treatment of several inflammatory diseases. In the phase 2 EQUATOR trial (NCT03101670), FIL was efficacious vs placebo (PBO) in patients… read more here.
Keywords: abbvie amgen; response; celgene; janssen lilly ... See more keywords
THU0366 MAGNETIC RESONANCE IMAGING IN COMPARISON WITH CONVENTIONAL RADIOGRAPHY FOR DETECTION OF STRUCTURAL CHANGES TYPICAL FOR SPA – DATA FROM THE ASSESSMENT OF SPONDYLOARTHRITIS INTERNATIONAL SOCIETY (ASAS) COHORT
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DOI: 10.1136/annrheumdis-2019-eular.7901
Abstract: Background In axial spondyloarthritis, magnetic resonance imaging (MRI) is useful for depicting active inflammatory lesions. The utility of MRI to display structural changes is not that well established. Objectives Comparison of MRI and conventional radiography… read more here.
Keywords: abbvie; pfizer; novartis pfizer; janssen ... See more keywords
AB0301 SARILUMAB AS MONOTHERAPY OR IN COMBINATION WITH CONVENTIONAL SYNTHETIC DMARDS IN PATIENTS WITH RHEUMATOID ARTHRITIS: 12-WEEK TREATMENT RESULTS FROM A MULTICENTER, OPEN-LABEL, PROSPECTIVE, SINGLE-ARM OBSERVATIONAL STUDY
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DOI: 10.1136/annrheumdis-2020-eular.1972
Abstract: Background: Due to strict inclusion/exclusion criteria, randomized controlled trials (RCTs) may not represent the heterogeneous rheumatoid arthritis (RA) population encountered in routine clinical practice; longitudinal observational studies are needed to complement learnings from RCTs. The… read more here.
Keywords: sanofi; combination; treatment; genzyme ... See more keywords