Hb S (HBB: c.20A>T) Characteristics by High Performance Liquid Chromatography in Patients with Sickle Cell Disease Receiving the Novel Agent Voxelotor.
Sign Up to like & getrecommendations! Published in 2021 at "Hemoglobin"
DOI: 10.1080/03630269.2020.1788074
Abstract: Voxelotor is a novel agent in the management of sickle cell disease. It is an inhibitor of Hb S (HBB: c.20A>T) polymerization that reversibly binds to hemoglobin (Hb), stabilizing it in the oxygenated state that… read more here.
Keywords: voxelotor; cell disease; novel agent; hbb 20a ... See more keywords
Inclisiran: A Novel Agent for Lowering Apolipoprotein B-Containing Lipoproteins.
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DOI: 10.1097/fjc.0000000000001053
Abstract: ABSTRACT Hypercholesterolemia is a leading cause of cardiovascular morbidity and mortality. Accordingly, efforts to lower apolipoprotein B-containing lipoproteins in plasma are the centerpiece of strategies for cardiovascular prevention and treatment in primary and secondary management.… read more here.
Keywords: novel agent; lowering apolipoprotein; containing lipoproteins; inclisiran novel ... See more keywords
A Road Map for Designing Phase I Clinical Trials of Radiotherapy–Novel Agent Combinations
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DOI: 10.1158/1078-0432.ccr-21-4087
Abstract: Abstract Radiotherapy has proven efficacy in a wide range of cancers. There is growing interest in evaluating radiotherapy–novel agent combinations and a drive to initiate this earlier in the clinical development of the novel agent,… read more here.
Keywords: radiotherapy novel; novel agent; design; road map ... See more keywords
Romosozumab: A Novel Agent in the Treatment for Postmenopausal Osteoporosis
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DOI: 10.1177/8755122520967632
Abstract: Objective: To review the safety and efficacy of romosozumab (Evenity) in the treatment of osteoporosis in women. Data Sources: An English-language search of PubMed and Medline (1966 to August 2020) was conducted using the keywords… read more here.
Keywords: romosozumab novel; treatment; novel agent; romosozumab ... See more keywords
Hematopoietic Stem Cell Transplant in Novel Agent Era Is Associated with Improved Survival in Relapsed and Refractory Peripheral T-Cell Lymphoma
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DOI: 10.1182/blood-2018-99-111476
Abstract: Background Conventional salvage chemotherapy has limited efficacy in relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL). In the last decade, several novel agents, including pralatrexate, an antifolate, brentuximab vedotin (BV), a CD30-directed antibody-drug conjugate, and… read more here.
Keywords: relapsed refractory; consultancy; novel agent; cell ... See more keywords
Clinical and cytogenetic features of nonsecretory multiple myeloma (NSMM) in the era of novel agent induction therapy: The Mayo Clinic experience.
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DOI: 10.1200/jco.2019.37.15_suppl.e19519
Abstract: e19519 Background: NSMM is a rare subtype of myeloma that has not been well characterized in the era of novel agent induction therapy. Thus, we evaluated the clinical and cytogenetic features of patients with newly… read more here.
Keywords: myeloma; era novel; novel agent; agent induction ... See more keywords
Impact of novel agent therapies on immune cell subsets and infectious complications in patients with relapsed/refractory multiple myeloma
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DOI: 10.3389/fonc.2023.1078725
Abstract: Introduction Infections are a leading cause of morbidity and mortality in patients with multiple myeloma (MM). Methods To examine the effects of modern second-generation novel agent therapy on immune cell subsets, in particular CD4+-T-cells, and… read more here.
Keywords: novel agent; cell; cd4; immune cell ... See more keywords
A novel agent for myeloma causing toxic keratopathy, belantamab mafodotin: a case report and literature review.
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DOI: 10.5935/0004-2749.2021-0358
Abstract: A 60-year-old-male with refractory relapsed multiple myeloma presented with redness, pain, foreign body sensation, and blurred vision in both eyes that gradually increased after his third belantamab mafotodin infusion. Biomicroscopy revealed bilateral microcyst-like epithelial changes… read more here.
Keywords: belantamab; novel agent; agent myeloma; belantamab mafodotin ... See more keywords