Outcome of older myeloma patients in relationship to comorbidities and availability of second‐generation novel agents in a real‐life setting
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3024
Abstract: Major improvements in outcome of older patients with multiple myeloma (MM) have been achieved with the introduction of novel agents. Their impact in real‐life treatment of older patients is unclear. In this single center retrospective… read more here.
Keywords: second generation; real life; novel; outcome older ... See more keywords
Novel agents for sperm purification, sorting, and imaging
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DOI: 10.1002/mrd.22831
Abstract: The stringent selection of viable spermatozoa ensures the transmission of high‐quality genetic material to the egg during fertilization. Sperm heterogeneity within or between ejaculates and between males obliges varied post‐collection handling of semen to assure… read more here.
Keywords: sperm purification; sorting imaging; novel agents; purification sorting ... See more keywords
The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de‐risk trial programmes of novel agents
Sign Up to like & getrecommendations! Published in 2023 at "World Psychiatry"
DOI: 10.1002/wps.21056
Abstract: Despite considerable progress in pharmacotherapy over the past seven decades, many mental disorders remain insufficiently treated. This situation is in part due to the limited knowledge of the pathophysiology of these disorders and the lack… read more here.
Keywords: phase; trial; trial programmes; programmes novel ... See more keywords
The role of novel agents for consolidation after autologous transplantation in newly diagnosed multiple myeloma: a systematic review
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04316-8
Abstract: Despite the increasing inclusion of novel agents within the multiple myeloma (MM) treatment sequence, their role for posttransplant consolidation therapy remains unclear. We systematically reviewed studies evaluating the efficacy of novel agent consolidation. We identified… read more here.
Keywords: consolidation therapy; consolidation; novel agents; multiple myeloma ... See more keywords
Novel Agents in the Treatment of Thymic Malignancies
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DOI: 10.1007/s11864-017-0495-8
Abstract: Opinion statementThe management of thymic tumours is a paradigm of multidisciplinary collaboration. Chemotherapy may be administered part of curative-intent sequential strategy integrating subsequent surgery or radiotherapy, or as an exclusive treatment if local treatment is… read more here.
Keywords: thymic malignancies; treatment; novel agents; treatment thymic ... See more keywords
Novel Targeted Therapeutics in Acute Myeloid Leukemia: an Embarrassment of Riches
Sign Up to like & getrecommendations! Published in 2021 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-021-00621-9
Abstract: Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow that has a poor prognosis with traditional cytotoxic chemotherapy, especially in elderly patients. In recent years, small molecule inhibitors targeting AML-associated IDH1, IDH2,… read more here.
Keywords: myeloid leukemia; targeted therapeutics; novel agents; novel targeted ... See more keywords
Novel Agents Beyond Immunomodulatory Agents and Phosphoinositide-3-Kinase for Follicular Lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2020.03.002
Abstract: Follicular lymphoma is the most common indolent non-Hodgkin lymphoma. Although median overall survival rates exceed 12 years with rituximab, follicular lymphoma remains largely incurable. The growing understanding of the molecular drivers of lymphomagenesis and the tumor… read more here.
Keywords: lymphoma; agents beyond; novel agents; follicular lymphoma ... See more keywords
Primary plasma cell leukemia in the era of novel agents for myeloma - a multicenter retrospective analysis of outcome.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.02.010
Abstract: Primary plasma cell leukemia (PPCL) is a rare form of multiple myeloma with a dismal prognosis. This retrospective multi-center study examines the national experience of PPCL in the era of novel agents. During 2002-2016, thirty-nine… read more here.
Keywords: primary plasma; cell leukemia; novel agents; plasma cell ... See more keywords
The NLR and LMR ratio in newly diagnosed MM patients treated upfront with novel agents
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DOI: 10.1038/s41408-017-0019-6
Abstract: Multiple myeloma (MM) is the second most frequent hematological neoplasia, characterized by the accumulation of malignant plasma cells within the marrow microenvironment leading to variable anemia, bone pain, renal impairment, hypercalcemia and infections. Virtually all… read more here.
Keywords: treated upfront; patients treated; novel agents; ratio ... See more keywords
Dose-dependent role of novel agents emodin and BTB14431 in colonic cancer treatment in rats
Sign Up to like & getrecommendations! Published in 2017 at "Acta Chirurgica Belgica"
DOI: 10.1080/00015458.2017.1341145
Abstract: Abstract Background: BTB14431 is an in silico homolog to emodin. Both were found to possess anti-tumor effects in vitro. The aim of this work was to analyze the tumor suppressing effects of both molecules in… read more here.
Keywords: tumor; treatment; novel agents; dose dependent ... See more keywords
In silico studies and the design of novel agents for the treatment of systemic tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1511476
Abstract: Abstract Tuberculosis (TB) is an ancient infectious disease, which re-emerged with the appearance of multidrug-resistant strains and acquired immune deficiency syndrome. Enoyl-acyl-carrier protein reductase (InhA) has emerged as a promising target for the development of… read more here.
Keywords: studies design; silico studies; design novel; novel agents ... See more keywords