Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.
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DOI: 10.1016/j.ejmech.2016.10.051
Abstract: Thirty-two novel 3-alkylsulfanyl-1,2,4-triazole derivatives, designed as cis-restricted combretastatin A-4 analogues, were synthesized and evaluated for their antiproliferative activities. The results indicated that analogue 20 showed more potent antiproliferative activities against PC-3 cell lines than positive control… read more here.
Keywords: design synthesis; restricted combretastatin; novel alkylsulfanyl; cis restricted ... See more keywords