Synthesis, bioinformatics and biological evaluation of novel α-aminophosphonates as antibacterial agents: DFT, Molecular Docking and ADME/T Studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131635
Abstract: Abstract Novel α-aminophosphonates containing 1,2,3-oxathizolidine-2,2-dioxide moiety were described. These molecules were synthesized within two steps starting by the condensation of three compounds (β-amino alcohols, benzaldehyde and triethylphosphite) via Kabachnik-Fields reaction followed by cyclisation with sulfuryl… read more here.
Keywords: novel aminophosphonates; synthesis bioinformatics; bioinformatics biological; evaluation ... See more keywords
Novel α-Aminophosphonates and α-Aminophosphonic Acids: Synthesis, Molecular Docking and Evaluation of Antifungal Activity against Scedosporium Species
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DOI: 10.3390/molecules27123886
Abstract: The Scedosporium genus is an emerging pathogen with worldwide prevalence and high mortality rates that gives multidrug resistance to antifungals; therefore, pharmacological alternatives must be sought for the treatment of diseases caused by this fungus.… read more here.
Keywords: antifungal activity; compound; novel aminophosphonates; scedosporium ... See more keywords