Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.033
Abstract: Hederagenin is a naturally occurring pentacyclic triterpenoids compound with multiple pharmacological activities. We recently showed that H6, a synthetic derivative of hederagenin, could enhance the anticancer activity of paclitaxel in drug-resistant cells in vitro and in vivo,… read more here.
Keywords: drug resistance; reversal; drug; drug resistant ... See more keywords
Effect of fentanyl and its three novel analogues on biochemical, oxidative, histological, and neuroadaptive markers after sub-acute exposure in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117400
Abstract: AIMS Comparative sub-acute toxicity, including tolerance and dependence potential of fentanyl and its three novel and potent analogues was determined in mice. MAIN METHODS Comparative sub-acute (21 d, intraperitoneal; 1/10 LD50) toxicity of fentanyl and its… read more here.
Keywords: liver kidney; sub acute; biochemical oxidative; three novel ... See more keywords
Design, synthesis, and antitumor activity of novel oleanolic acid analogues targeting EGFR.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2206572
Abstract: Based on the simulated docking of Epidermal growth factor receptor inhibitors with known active small molecule compounds, computer-aided drug design technology was used to analyze key amino acid fragments and determine the active groups binding… read more here.
Keywords: oleanolic acid; design synthesis; antitumor; novel analogues ... See more keywords
Synthesis, Characterization and Anticancer Evaluation of Novel Analogues of Pyrazoles
Sign Up to like & getrecommendations! Published in 2021 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2021.00382
Abstract: In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on… read more here.
Keywords: synthesis characterization; characterization anticancer; evaluation novel; novel ... See more keywords