Discovery and Evaluation of Novel Angular Fused Pyridoquinazolinonecarboxamides as RNA Polymerase I Inhibitors.
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DOI: 10.1021/acsmedchemlett.1c00660
Abstract: RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) into the 47S ribosomal RNA (rRNA) precursor. Further processing produces the 28S, 5.8S, and 18S rRNAs that are assembled into mature ribosomes. Many cancers exhibit higher… read more here.
Keywords: polymerase; evaluation novel; rna polymerase; novel angular ... See more keywords