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Published in 2017 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.791
Abstract: We report pharmacokinetics, pharmacodynamics, and safety of a novel anti‐CD28 domain antibody antagonist (lulizumab pegol) in healthy subjects following single‐ or multiple‐dose administration. A minimal anticipated biological effect level approach was used to select a…
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Keywords:
antibody antagonist;
anti cd28;
novel anti;
domain antibody ... See more keywords
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Published in 2017 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1427
Abstract: Chronic inflammatory diseases and persistent pain of different origin represent common medical, social, and economic burden, and their pharmacotherapy is still an unresolved issue. Therefore, there is a great and urgent need to develop anti-inflammatory…
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Keywords:
anti inflammatory;
challenges develop;
develop novel;
inflammatory ... See more keywords
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Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02699-5
Abstract: The widespread deaths of tuberculosis from many decades demands an urgent need for the development of novel anti-tubercular scaffolds that are more potent and highly selective with lower cytotoxicity. Isatin hybrids are endowed with an…
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Keywords:
novel anti;
anti tubercular;
hybrids novel;
repositioning isatin ... See more keywords
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Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00962-3
Abstract: Introduction Liraglutide has several non-glycemic effects, including those on plasma lipids and lipoproteins, contributing to its cardiovascular benefit; however, the exact underlying mechanisms remain unclear. We investigated a novel anti-atherogenic effect of liraglutide in a…
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Keywords:
anti atherogenic;
small dense;
dense;
novel anti ... See more keywords
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Published in 2021 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2021.116749
Abstract: Abstract During the outbreak of COVID-19, the fogging of goggles was a fatal problem for doctors. At present, there are many ways to prevent fogging by adjusting surface wettability. However, the mechanical properties of most…
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Keywords:
novel anti;
anti fog;
fog high;
resistance ... See more keywords
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Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.11.010
Abstract: Article history: Received 15 November 2017 Accepted 15 November 2017 Available online 16 November 2017 example targeting Raf-1, Bcr, and Cdc25 phosphatase. Deguelin has the potential to impair 14-3-3 protein function through inhibition of Aurora…
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Keywords:
november 2017;
tumorigenic agent;
anti tumorigenic;
novel anti ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.10.008
Abstract: VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homology along the kinase domain of angiogenic RTKs. Biological…
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Keywords:
target;
diaryl thiourea;
novel anti;
indazole amine ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.10.030
Abstract: Herein, we embarked on a structural optimization campaign aiming at the discovery of second generation anti-angiogenesis agents with our previously reported BPS-7 as lead compound. A library of 27 compounds has been afforded based on…
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Keywords:
anti angiogenesis;
tie ephb4;
novel anti;
angiogenesis agents ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.02.037
Abstract: CGRP, known as the most potent vasodilator substance, plays an important role in hypertension initiation and development. TRPV1 and TRPA1 are critical in promoting the synthesis and release of CGRP, thereby regulating the cardiovascular tone.…
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Keywords:
release cgrp;
anti hypertensive;
novel anti;
rutaecarpine ... See more keywords
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Published in 2018 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2018.02.004
Abstract: The Coenzyme A (CoA), as a cofactor involved in >100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan…
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Keywords:
pank;
pantothenate kinase;
kinase;
novel anti ... See more keywords
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Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.06.034
Abstract: Printing technologies have been forecast to initiate a new era of personalised medicine in pharmaceuticals. To facilitate integration, a non-destructive and robust method of product authenticity is required. This study reports, for the first time,…
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Keywords:
material inks;
drug;
novel anti;
anti counterfeit ... See more keywords