Identification and Evaluation of Brominated Carbazoles as a Novel Antibiotic Adjuvant Scaffold in MRSA
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.1c00680
Abstract: Antibiotic-resistant infections are a pressing global concern, causing millions of deaths each year. Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of nosocomial infections in healthcare settings and is increasingly responsible for community-acquired infections that… read more here.
Keywords: identification evaluation; brominated carbazoles; evaluation brominated; novel antibiotic ... See more keywords
Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00393-22
Abstract: Many antibiotics were originally discovered from microbes. However, in recent decades, resistance to current treatments has risen, while novel antibiotic discovery has become increasingly challenging. ABSTRACT Bacterial natural products have historically been a deep source… read more here.
Keywords: novel antibiotic; recent decades; resistance; microbial interactions ... See more keywords
Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Resistance and Infection Control"
DOI: 10.1186/s13756-017-0279-8
Abstract: Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically… read more here.
Keywords: burkholderia cepacia; combinations proposed; antibiotic combinations; cepacia complex ... See more keywords
Editorial: The development and utilization of novel antibiotic alternatives
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1008850
Abstract: COPYRIGHT © 2022 Jiajun, Wenyu, KHosravi-Darani and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,… read more here.
Keywords: development utilization; novel antibiotic; editorial development; utilization novel ... See more keywords
Macromolecular Structure Assembly as a Novel Antibiotic Target
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DOI: 10.3390/antibiotics11070937
Abstract: This review discusses the inhibition of macromolecular structure formation as a novel and under-investigated drug target. The disruption of cell wall structures by penicillin-binding protein interactions is one potential target. Inhibition of DNA polymerase III… read more here.
Keywords: macromolecular structure; structure assembly; novel antibiotic; assembly novel ... See more keywords
Commonalities and Disparities between Endometriosis and Chronic Endometritis: Therapeutic Potential of Novel Antibiotic Treatment Strategy against Ectopic Endometrium
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032059
Abstract: Chronic endometritis (CE) is a local mucosal inflammatory disorder of the uterine lining, which is histopathologically recognized as the unusual infiltration of CD138(+) plasmacytes into the endometrial stromal compartment. Accumulating body of research documented that… read more here.
Keywords: potential novel; therapeutic potential; chronic endometritis; novel antibiotic ... See more keywords