In silico elucidation of novel anticancer lead molecules targeting human prostate specific gene-1 protein
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1477623
Abstract: Farheen Waziri, Ramachandran Vijayan, Tahreem Sahar, Shadab Anwar, Samudrala Gourinath, Swatantra Kumar Jain and Saima Wajid Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India; School of Life Sciences, Jawaharlal… read more here.
Keywords: new delhi; elucidation novel; silico elucidation; delhi india ... See more keywords
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2203389
Abstract: Abstract In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor… read more here.
Keywords: discovery sulfonamide; sulfonamide tethered; isatin derivatives; derivatives novel ... See more keywords
Development and Advances of Drugs for Cancer Theranostics - PART-IV.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in medicinal chemistry"
DOI: 10.2174/156802662118211007114155
Abstract: Cancer, a highly heterogeneous disease at intra/inter patient levels, is one of the most serious threats to human health across the world [1, 2]. Notwithstanding the noteworthy advances in its treat-ment, the morbidity and mortality… read more here.
Keywords: part; drug; novel anticancer; cancer ... See more keywords
Phthalazinone Scaffold:Emerging Tool in the Development of Target Based Novel Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666200807220146
Abstract: Phthalazinones are important nitrogen rich heterocyclic compound that has been topic of considerable medicinal interest because of their diversified pharmacological activities. This versatile scaffold forms a common structural feature for many bioactive compounds, which leads… read more here.
Keywords: novel anticancer; scaffold emerging; emerging tool; development ... See more keywords
WP1234—A Novel Anticancer Agent with Bifunctional Activity in a Glioblastoma Model
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112799
Abstract: Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis. Despite significant progress in drug development, the blood–brain barrier (BBB) continues to limit the use of novel chemotherapeutics.… read more here.
Keywords: glioblastoma; wp1234 novel; novel anticancer; activity ... See more keywords