mGlu receptors as potential targets for novel antidepressants
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DOI: 10.1016/j.coph.2018.02.001
Abstract: HighlightsmGlu2/3 antagonists exert ketamine‐like antidepressant effects in rodent models.mGlu2/3 antagonists shared some of their mechanisms with ketamine.mGlu5 NAMs exert antidepressant effects in rodent models.The mechanisms of mGlu5 NAMs may differ from those of ketamine.Antidepressant potential… read more here.
Keywords: novel antidepressants; mglu receptors; potential targets; receptor ... See more keywords
Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry
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DOI: 10.1055/a-1714-9097
Abstract: Introduction There is an imminent need for faster-acting and more effective antidepressants beyond the monoaminergic hypothesis. Methods We systematically searched the US Clinical Trials registry for antidepressant compounds with completed phase II and III trials.… read more here.
Keywords: clinical trials; phase; trials registry; phase iii ... See more keywords