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Published in 2017 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2017.02.067
Abstract: Abstract Because of the need for new antifungal materials with greater potency, microcrystals of α-Ag2WO4, a complex metal oxide, have been synthetized by a simple co-precipitation method, and their antifungal activity against Candida albicans has…
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Keywords:
novel antifungal;
ag2wo4 novel;
antifungal agent;
alpha ag2wo4 ... See more keywords
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Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04933
Abstract: The ever-increasing resistance of Fusarium graminearum has emerged as a pressing agricultural issue that could be settled by developing novel fungicides owning inimitable action mechanisms. With the aim of discovering novel antifungal leads inhibiting F.…
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Keywords:
leads inhibiting;
fusarium graminearum;
novel antifungal;
antifungal leads ... See more keywords
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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01299
Abstract: Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house…
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Keywords:
novel antifungal;
antifungal agents;
evaluation novel;
optimization evaluation ... See more keywords
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Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1261113
Abstract: ABSTRACT Introduction: Superficial infections involving the skin and mucosa are the most common fungal disease in humans. Fungi can also produce invasive infections (IFI), which are increasing in incidence among the growing population of immunocompromised…
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Keywords:
novel antifungal;
antifungal agents;
activity;
review ... See more keywords
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Published in 2017 at "Virulence"
DOI: 10.1080/21505594.2016.1276692
Abstract: The global impact of fungal infections on human health has recently been highlighted by several important publications, and advocacy groups. Although several factors undoubtedly contribute to the estimated 1.5 million deaths due to fungal disease…
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Keywords:
unmet clinical;
novel antifungal;
treatment;
antifungal drugs ... See more keywords
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Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01419-22
Abstract: Fosmanogepix (FMGX), a novel antifungal available in intravenous (IV) and oral formulations, has broad-spectrum activity against pathogenic yeasts and molds, including fungi resistant to standard of care antifungals. This multicenter, open-label, single-arm study evaluated FMGX…
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Keywords:
fosmanogepix;
safety;
candida auris;
caused candida ... See more keywords
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Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00075-22
Abstract: Pathogenic fungi represent a serious but underacknowledged threat to human health. The treatment and management of these infections relies heavily on the use of azole antifungals, a class of molecules that contain a five-membered nitrogen-containing…
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Keywords:
antifungal activity;
disubstituted pyridine;
novel antifungal;
chemical ... See more keywords
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Published in 2022 at "F1000Research"
DOI: 10.12688/f1000research.28327.2
Abstract: Invasive fungal diseases due to resistant yeasts and molds are an important and increasing public health threat, likely due to a growing population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics.…
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Keywords:
novel antifungal;
antifungal agents;
agents clinical;
clinical trials ... See more keywords
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Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4090734
Abstract: Benzoates as toxic intermediate are naturally produced by fungal intracellular metabolism, and CYP53 can specific transform the substrates. In the study, we constructed the CYP53 homology model and analyzed the corresponding active region. At the…
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Keywords:
antifungal phenylpyridines;
discovery novel;
phenylpyridines derivatives;
novel antifungal ... See more keywords
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Published in 2023 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s375625
Abstract: Abstract Invasive candidiasis (IC), due to the yeast pathogen Candida, is still a major cause of in-hospital morbidity and mortality. The limited number of antifungal drug classes and the emergence of multi-resistant Candida species, such…
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Keywords:
approaches invasive;
novel therapeutic;
candidiasis;
novel antifungal ... See more keywords
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Published in 2020 at "Journal of Environmental Biology"
DOI: 10.22438/jeb/41/3/mrn-1266
Abstract: The yield of purified antifungal protein was estimated -1 to be 0.96 mg 25 g seeds and its molecular mass determined by SDS PAGE was 52.9 kDa. The purified protein exhibited antifungal activity against phytopathogenic…
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Keywords:
protein;
characterization novel;
protein acacia;
novel antifungal ... See more keywords