Umbelliferone–oxindole hybrids as novel apoptosis inducing agents
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c7nj02578e
Abstract: In furtherance of our endeavour towards the synthesis of novel bioactive agents, a panel of (E)-3-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)indolin-2-one derivatives were synthesized using diverse 5-substituted oxindoles and 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde (3a). These synthesized analogues were further evaluated for their in… read more here.
Keywords: novel apoptosis; umbelliferone oxindole; apoptosis inducing; apoptosis ... See more keywords
Novel Apoptosis-Inducing Agents for the Treatment of Cancer, a New Arsenal in the Toolbox
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11081087
Abstract: Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis pathways are especially critical as they confer resistance to conventional anti-cancer therapeutics, e.g., chemotherapy, radiotherapy, and targeted therapeutics. Thus, successful induction of… read more here.
Keywords: novel apoptosis; inducing agents; apoptosis inducing; apoptosis ... See more keywords