Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells.
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DOI: 10.1016/j.ejmech.2017.06.023
Abstract: A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were designed, synthesized and evaluated for biological activities in vitro. Most compounds exhibited highly antiproliferative activities against all tested tumor cell lines including A431, A549, NCI-H1975 and… read more here.
Keywords: egfr; derivatives propen; antiproliferative activities; novel arylaminoquinazoline ... See more keywords